Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota

Zeng, Wu; Wu, An Guo; Zhou, Xiao-Gang; Khan, Imran; Zhang, Rui Long; Lo, Hang Hong; Li, Qu; Song, Lin Lin; Yun, Xiao Yun; Wang, Hui Miao; Chen, Juan; Ng, Jerome P. L.; Ren, Fangfang; Yuan, Si Yu; Yu, Lu; Tang, Yong; Huang, Guo Xin; Wong, Vincent Kam Wai; Chung, Sookja K.; Mok, Simon Wing Fai; Qin, Da; Sun, Hua; Liu, Liang; Hsiao, W.L. Wendy; Law, Betty Yuen Kwan

doi:10.1016/j.phrs.2021.105697

Cited by 17 publications

(7 citation statements)

References 75 publications

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“…Among them, anshinone and danshensu in Dan-Shen, paeoniflorin in Bai-Shao, and the volatile oil components such as β-asarone in Shi-Chang-Pu can directly cross the blood-brain barrier (BBB) to improve cognitive impairment (Sun et al, 2020). In addition, the main active ingredients in ZBPYR, such as ginsenosides in Hong-Shen (Sun et al, 2020), yam polysaccharides in Shan-Yao (Pang et al, 2020), and saponins in Yuan-Zhi (Zeng et al, 2021), cannot directly cross the BBB. It is necessary to transform the metabolism of macromolecular substances into small molecular metabolites through the mediation of the gut microbiota and then cross the BBB to play a biological effect of improving cognitive function.…”

Section: Discussionmentioning

confidence: 99%

ZiBuPiYin Recipe Prevented and Treated Cognitive Decline in ZDF Rats With Diabetes-Associated Cognitive Decline via Microbiota–Gut–Brain Axis Dialogue

Feng

Zhan

et al. 2021

Front. Cell Dev. Biol.

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Gut microbiota is becoming one of the key determinants in human health and disease. Shifts in gut microbiota composition affect cognitive function and provide new insights for the prevention and treatment of neurological diseases. Diabetes-associated cognitive decline (DACD) is one of the central nervous system complications of type 2 diabetes mellitus (T2DM). ZiBuPiYin recipe (ZBPYR), a traditional Chinese medicine (TCM) formula, has long been used for the treatment of T2DM and prevention of DACD. However, the contribution of ZBPYR treatment to the interaction between the gut microbiota and metabolism for preventing and treating DACD remains to be clarified. Here, we investigate whether the gut microbiota plays a key role in ZBPYR-mediated prevention of DACD and treatment of T2DM via incorporating microbiomics and metabolomics, and investigate the links between the microbiota–gut–brain axis interaction and the efficacy of ZBPYR in ZDF rats. In the current study, we found that ZBPYR treatment produced lasting changes in gut microbiota community and metabolites and remotely affected hippocampus metabolic changes, thereby improving memory deficits and reversing β-amyloid deposition and insulin resistance in the brain of ZDF rats from T2DM to DACD. This may be related to a series of metabolic changes affected by gut microbiota, including alanine, aspartic acid, and glutamic acid metabolism; branched-chain amino acid metabolism; short-chain fatty acid metabolism; and linoleic acid/unsaturated fatty acid metabolism. In summary, this study demonstrates that prevention and treatment of DACD by ZBPYR partly depends on the gut microbiota, and the regulatory effects of bacteria-derived metabolites and microbiota–gut–brain axis are important protective mechanisms of ZBPYR.

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Section: Discussionmentioning

confidence: 99%

ZiBuPiYin Recipe Prevented and Treated Cognitive Decline in ZDF Rats With Diabetes-Associated Cognitive Decline via Microbiota–Gut–Brain Axis Dialogue

Feng

Zhan

et al. 2021

Front. Cell Dev. Biol.

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“…Moreover, previous studies found that C3 and C4 were positively correlated with age and inversely correlated with life expectancy in centenarians 48 . Another study demonstrated that low levels of C3 delayed renal senescence, 49 and that the use of Radix polygalae saponins to affect C3 expression could also extend the lifespan of C. elegans 50 . It is clear that complement and aging are closely linked, but the role of complement components and aging‐related VC is unclear.…”

Section: The Activation Of Complement System In Vcmentioning

confidence: 99%

New insight of complement system in the process of vascular calcification

Liu

Luo

Huang

2023

J Cellular Molecular Medi

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The complement system defences against pathogenic microbes and modulates immune homeostasis by interacting with the innate and adaptive immune systems. Dysregulation, impairment or inadvertent activation of complement system contributes to the pathogenesis of some autoimmune diseases and cardiovascular diseases (CVD). Vascular calcification is the pivotal pathological basis of CVD, and contributes to the high morbidity and mortality of CVD. Increasing evidences indicate that the complement system plays a key role in chronic kidney diseases, atherosclerosis, diabetes mellitus and aging‐related diseases, which are closely related with vascular calcification. However, the effect of complement system on vascular calcification is still unclear. In this review, we summarize current evidences about the activation of complement system in vascular calcification. We also describe the complex network of complement system and vascular smooth muscle cells osteogenic transdifferentiation, systemic inflammation, endoplasmic reticulum stress, extracellular matrix remodelling, oxidative stress, apoptosis in vascular calcification. Hence, providing a better understanding of the potential relationship between complement system and vascular calcification, so as to provide a direction for slowing the progression of this burgeoning health concern.

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“…Complement C3 and C4 levels have been shown to correlate with age [ 5 ], and longevity has been shown to have a negative connection with C3/C4 levels, suggesting that high C3 levels are harmful to longevity. Another study demonstrated that low levels of C3 delayed renal senescence [ 25 ] and that the use of Radix polygalae saponins to affect C3 expression could also extend the lifespan of C. elegans [ 26 ]. It is clear that complement and aging are closely linked, but the relationship between them is unclear.…”

Section: Complement and Agingmentioning

confidence: 99%

The Complement System, Aging, and Aging-Related Diseases

Zheng

Zhang

et al. 2022

IJMS

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The complement system is a part of the immune system and consists of multiple complement components with biological functions such as defense against pathogens and immunomodulation. The complement system has three activation pathways: the classical pathway, the lectin pathway, and the alternative pathway. Increasing evidence indicates that the complement system plays a role in aging. Complement plays a role in inflammatory processes, metabolism, apoptosis, mitochondrial function, and Wnt signaling pathways. In addition, the complement system plays a significant role in aging-related diseases, including Alzheimer’s disease, age-related macular degeneration, and osteoarthritis. However, the effect of complement on aging and aging-related diseases is still unclear. Thus, a better understanding of the potential relationship between complement, aging, and aging-related diseases will provide molecular targets for treating aging, while focusing on the balance of complement in during treatment. Inhibition of a single component does not result in a good outcome. In this review, we discussed the research progress and effects of complement in aging and aging-related diseases.

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Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota

Cited by 17 publications

References 75 publications

ZiBuPiYin Recipe Prevented and Treated Cognitive Decline in ZDF Rats With Diabetes-Associated Cognitive Decline via Microbiota–Gut–Brain Axis Dialogue

ZiBuPiYin Recipe Prevented and Treated Cognitive Decline in ZDF Rats With Diabetes-Associated Cognitive Decline via Microbiota–Gut–Brain Axis Dialogue

New insight of complement system in the process of vascular calcification

The Complement System, Aging, and Aging-Related Diseases

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