Saponin surfactants used in drug delivery systems: A new application for natural medicine components

Liao, Yuyao; Li, Zhixun; Zhou, Qing; Sheng, Mengke; Qu, Qingsong; Shi, Yanshuang; Yang, Jiaqi; Lv, Lijing; Dai, Xingxing; Shi, Xiaowen

doi:10.1016/j.ijpharm.2021.120709

Cited by 63 publications

(49 citation statements)

References 82 publications

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“…As an amphiphilic naturally occurring compound, saponin has attracted the potential as carriers in drug delivery where studies have reported improved bioavailability ( Liao et al, 2021 ). In exon skipping, the interesting use of saponins as vehicles was first demonstrated and had provided exciting results, digitonin being the most effective.…”

Section: Resultsmentioning

confidence: 99%

A Decade of Progress in Gene Targeted Therapeutic Strategies in Duchenne Muscular Dystrophy: A Systematic Review

Liang

Sulaiman

Yazid

2022

Front. Bioeng. Biotechnol.

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As one of the most severe forms of muscle dystrophy, Duchenne muscular dystrophy (DMD) results in progressive muscle wasting, ultimately resulting in premature death due to cardiomyopathy. In the many years of research, the solution to DMD remains palliative. Although numerous studies including clinical trials have provided promising results, approved drugs, even, the therapeutic window is still minimal with many shortcomings to be addressed. Logically, to combat DMD that arose from a single genetic mutation with gene therapy made sense. However, gene-based strategies as a treatment option are no stranger to drawbacks and limitations such as the size of the dystrophin gene and possibilities of vectors to elicit immune responses. In this systematic review, we aim to provide a comprehensive compilation on gene-based therapeutic strategies and critically evaluate the approaches relative to its efficacy and feasibility while addressing their current limitations. With the keywords “DMD AND Gene OR Genetic AND Therapy OR Treatment,” we reviewed papers published in Science Direct, PubMed, and ProQuest over the past decade (2012–2021).

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Section: Resultsmentioning

confidence: 99%

A Decade of Progress in Gene Targeted Therapeutic Strategies in Duchenne Muscular Dystrophy: A Systematic Review

Liang

Sulaiman

Yazid

2022

Front. Bioeng. Biotechnol.

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“…The amphiphilic characteristic structure endows saponins with excellent self-assembly property and surface activity. Considering the molecular weight (MW) of most saponins is usually larger than 1000 and they are one of the well-known plant-derived biosurfactants like escin [ 56 ], tea saponin [ 57 ], Quillaja saponin [ 58 ], platycodin [ 59 , 60 ], ginsenosides [ 61 ] and so forth, several typical saponins with MW<1000 will be emphasized in this review.…”

Section: Diversity Of Self-assembled Natural Molecular Structuresmentioning

confidence: 99%

Supramolecular assemblies based on natural small molecules: Union would be effective

Hou

Zou

et al. 2022

Materials Today Bio

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“…Saponins exhibit their dual roles, a therapeutic ability due to their pharmacological effects, and an excipient because of inherently surfactant properties. Saponins can enhance the solubility of hydrophobic drugs and the skin's permeability without affecting the lipid membrane [19]. Polyphenols are valuable to decrease the perils of the diseases for humans because of their unique properties, such as antibacterial, antiviral, antioxidant, and anti-inflammatory effects [20].…”

Section: Preliminary Screening Of Phytochemicalsmentioning

confidence: 99%

“…However, the applications of those bioactive compounds could meet some difficulties. First, the harmful effects might come from saponins (hemolysis) [17], coumarins (anti-coagulant effect) [19], and cardiac glycosides (toxicity) [18] if the high dosage is utilized. Second, the bioactive compounds are unstable in physiological conditions or vastly scattered after treatment [11].…”

Section: Preliminary Screening Of Phytochemicalsmentioning

confidence: 99%

Supramolecular Gels Incorporating Cordyline terminalis Leaf Extract as a Polyphenol Release Scaffold for Biomedical Applications

Thi

Tran

Thi

et al. 2021

IJMS

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Cordyline terminalis leaf extract (aqCT) possesses abundant polyphenols and other bioactive compounds, which are encapsulated in gelatin–polyethylene glycol–tyramine (GPT)/alpha-cyclodextrin (α-CD) gels to form the additional functional materials for biomedical applications. In this study, the gel compositions are optimized, and the GPT/α-CD ratios equal to or less than one half for solidification are found. The gelation time varies from 40.7 min to 5.0 h depending on the increase in GPT/α-CD ratios and aqCT amount. The aqCT extract disturbs the hydrogen bonding and host–guest inclusion of GPT/α-CD gel networks, postponing the gelation. Scanning electron microscope observation shows that all gels with or without aqCT possess a microarchitecture and porosity. GPT/α-CD/aqCT gels could release polyphenols from 110 to 350 nmol/mL at the first hour and sustainably from 5.5 to 20.2 nmol/mL for the following hours, which is controlled by feeding the aqCT amount and gel properties. GPT/α-CD/aqCT gels achieved significant antioxidant activity through a 100% scavenging DPPH radical. In addition, all gels are non-cytotoxic with a cell viability more than 85%. Especially, the GPT3.75α-CD10.5aqCT gels with aqCT amount of 3.1–12.5 mg/mL immensely enhanced the cell proliferation of GPT3.75α-CD10.5 gel without extract. These results suggest that the inherent bioactivities of aqCT endowed the resulting GPT/α-CD/aqCT gels with effective antioxidant and high biocompatibility, and natural polyphenols sustainably release a unique platform for a drug delivery system or other biomedical applications.

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Saponin surfactants used in drug delivery systems: A new application for natural medicine components

Cited by 63 publications

References 82 publications

A Decade of Progress in Gene Targeted Therapeutic Strategies in Duchenne Muscular Dystrophy: A Systematic Review

A Decade of Progress in Gene Targeted Therapeutic Strategies in Duchenne Muscular Dystrophy: A Systematic Review

Supramolecular assemblies based on natural small molecules: Union would be effective

Supramolecular Gels Incorporating Cordyline terminalis Leaf Extract as a Polyphenol Release Scaffold for Biomedical Applications

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