Sapogeninas esteroídicas em sisal

Zullo, Marco António Teixeira; Azzini, Anisio; Salgado, Antônio Luiz de Barros; Ciaramello, Dirceu

doi:10.1590/s0006-87051989000100003

Cited by 6 publications

(2 citation statements)

References 6 publications

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“…Furthermore, the larvicidal activity of A. sisalana against Ae. aegypti larvae found in the present study may be due to the fact that A. sisalana crude extract is rich in steroidal sapogenins, including the hecogenin acetate and tigogenin (Zullo et al 1989).…”

Section: Discussionmentioning

confidence: 68%

The larvicidal activity of Agave sisalana against L4 larvae of Aedes aegypti is mediated by internal necrosis and inhibition of nitric oxide production

et al. 2014

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Dengue is a viral disease that affects about 50 million people per year around the world. The aim of this study was to investigate the larvicidal activity of Agave sisalana crude extract in order to develop a new insecticide against Aedes aegypti. In larvicidal activity assays, fourth-stage Ae. aegypti larvae were exposed to different concentrations of A. sisalana crude extract for 3, 6, 12, and 24 h for determining the LC50. Next, we explored its cytotoxic activity by flow cytometry. Furthermore, histological alterations were confirmed by histopathological analysis, and the nitric oxide (NO) production by hemocytes was checked after different periods of exposure to A. sisalana crude extract. The LC50 was 4.5 ± 0.07 mg/mL. In addition, flow cytometry revealed an increase of cellular necrosis (21 and 16.5 % after 12 and 24 h, respectively) in larvae that were exposed to A. sisalana crude extract. The histological analysis revealed cell lysis and destruction of the peritrophic membrane. Furthermore, there was a reduction in the concentration of NO in the hemolymph from larvae exposed to A. sisalana crude extract after 3, 6, and 24 h (5.3 ± 4.3 vs. 22.7 ± 5.2 μM, 4.3 ± 5.5 vs. 25.4 ± 6.6 μM, and 6 ± 1.7 vs. 37.1 ± 7.8 μM, respectively). Our findings show that A. sisalana crude extract constitutes an effective larvicidal agent against Ae. aegypti larvae due to its necrotizing activity in hemocytes and inhibition of the NO production.

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Section: Discussionmentioning

confidence: 68%

The larvicidal activity of Agave sisalana against L4 larvae of Aedes aegypti is mediated by internal necrosis and inhibition of nitric oxide production

et al. 2014

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“…Among the secondary metabolites produced by plants, saponins constitute one of the most prominent classes due to their wide distribution in the plant kingdom and their important biological activities (Kaiser et al 2010). Hecogenin, which is isolated from Agave sisalanap, belongs to the class of steroidal saponins or sapogenins, in dried sisal leaves (Cripps and Bluden 1978;Zullo et al 1984;Zullo et al 1989) anti-in ammatory (Ingawale and Patel, 2016) and gastroprotective ). Hecogenin, like other sapogenins obtained, is relatively unstable in the environment and can easily hydrolyze.…”

Section: Introductionmentioning

confidence: 99%

Antiulcerogenic and healing activity of hecogenin acetate in rodents

Sousa

Neto²,

Costa³

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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Peptic ulcers are lesions in the gastric and duodenal mucosa generated by an imbalance between protective factors (gastroduodenal mucus secretion, bicarbonate production, adequate blood ow) and harmful factors (excess pepsin or hydrochloric acid). Some drugs used in peptic ulcer therapy are associated with adverse effects. The aim of this study was to evaluate the antiulcerogenic and healing activity of hecogenin acetate (HA) in acute and chronic models of gastric lesions in rodents. MethodsThe antiulcerogenic activity of HA was evaluated in models of gastric lesions induced by absolute ethanol and in acidi ed ethanol with HA (5; 10 and 20 mg/kg). For the model of gastric lesions induced by ischemia and reperfusion, rats were pre-treated with HA (5; 10, 20 mg/kg). After were submitted to 30 min of ischemia, followed by 1 h of reperfusion. To evaluate the healing activity was induced gastric ulcer using acetic acid (80%) in rats. After 24h they were treated for 7 consecutive days with HA (10 and 20 mg/kg). ResultsWere evaluated the possible signs of toxicity, measurement of the lesions, collagen deposition and histological analysis. HA signi cantly reduced the area of the lesion in models of gastric lesions induced by absolute and acidi ed ethanol, ischemia-induced gastric lesions and reperfusion, and regarding healing. In the collagen deposition, the presence and increase of collagen demonstrates healing effect. ConclusionThe AH has antiulcerogenic and healing potential demonstrated by the decrease in gastric injury and presence of collagen bers, respectively.

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Agavaceae Endl.

2012

Toxic Plants of North America

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Sapogeninas esteroídicas em sisal

Cited by 6 publications

References 6 publications

The larvicidal activity of Agave sisalana against L4 larvae of Aedes aegypti is mediated by internal necrosis and inhibition of nitric oxide production

The larvicidal activity of Agave sisalana against L4 larvae of Aedes aegypti is mediated by internal necrosis and inhibition of nitric oxide production

Antiulcerogenic and healing activity of hecogenin acetate in rodents

Agavaceae Endl.

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