Sapiens Mitochondrial DNA Genome Circular Long Range Numerical Meta Structures are Highly Correlated with Cancers and Genetic Diseases mtDNA Mutations

Abstract

Using the circular nature of the 16k base-pairs human mtDNA genome, we are looking for hypothetical proportions between the C+A and T+G bases. Remarkable proportions are thus discovered, the length of which may be much greater than the length of the genome. We then analyze the impact of evolution on these "numerical resonances" by comparing the referenced mtDNAs of Sapiens, Neanderthal and Denisova. Then, by analyzing 250 characteristic mutations associated with various pathologies, we establish a very strong formal causal correlation between these numerical meta structures and these referenced mutations. To summarize, we should think then research on the following situation: (a) Inputs: 250 cases of mtDNA mutations1 associated with various human diseases. (b) An operator: The exhaustive search for mtDNA genome "Fibonacci resonances" associated with these mutations. (c) A "binary" output: a common behavior of the mtDNA genome resulting from these 250 mutations disorders.

The Genetic Coding System and Unitary Matrices

“…One can note that our study belongs to the field of applications of algebraic methods and notions of quantum mechanics for modeling moleculargenetic structures where works of many authors exist, for example, the following [Dragovich, Dragovich, 2007;Dragovich, Khrennikov, Misic, 2017;Fimmel, Danielli, Strüngmann, 2013;Fimmel, Strüngmann, 2016;Igamberdiev, 1993;Ji, 2015Ji, , 2017Hu, Petoukhov, Petukhova, 2017;Matsuno, 1999Matsuno, , 2003Matsuno, , 2015Matsuno, Paton, 2000;Moon Ho Lee et al, 2017;Pellionis, 2008;Pellionisz et al, 2012;Penrose, 1996;Perez, 2010Perez, , 2013Perez, , 2017Petoukhov, 2008Petoukhov, , 2010aPetoukhov, ,b, 2011Petoukhov, , 2012Petoukhov, , 2015aPetoukhov, ,b,c,d,c, 2016Petoukhov, , 2017aPetoukhov, He, 2009;Petoukhov, Petukhova, 2017a,b;Petoukhov, Svirin, 2012;Rapoport, 2016a,b,c;Rumer, 1968;Simeonov, 2013;Stambuk, 1999].…”

CRISPR Technology Challenge Facing the Numerical Integrity of Whole Human Genome DNA

“…Particularly, it is found that the 3 HGOs calculated for the respective 3 genomes of Neanderthal, Sapiens (2003 Build34 and 2013 hg38 Sapiens) are very close to the ideal theoretical optimal HGO = 0.6909830056 (99.67% for the least optimal genome) [16][17][18][19][20][21][22][23][24][25][26][27][28][29]. It is also observed that female genomes (XX) are more optimal than male genomes (XY).…”

“…Finally, we note that it is the downstream region (Figure 3) that contributes the most to the superiority of optimality of sapiens hg38 compared to sapiens Build34. We have sorted the 24 chromosomes by increasing values of CG/TA ratios in the 3 cases of compared genomes [29][30][31][32][33][34][35]. (Table 1).…”

Why the genomic LOCATION of individual SNPs is FUNCTIONAL?

“…Other numerical codes of DNA and genomes were discovered during these 25 years [ 8,9,10,11]. Some of these codes, as will be the case here, are fractal [12,13,14,15,16,17,18]. …”