SAPHO syndrome with Takayasu arteritis successfully treated with tofacitinib

Abstract

SAPHO syndrome is an autoinflammatory disease with a variety of clinical manifestations, which may be accompanied by other systemic inflammatory diseases in addition to the typical manifestations of common synovitis, acne, pustulosis, hyperostosis, and osteitis. Here, we report the first case of SAPHO syndrome combined with Takayasu arteritis.

Unusual cause of inflammatory backache: SAPHO syndrome

“…However, the persistence of symptoms prompted a crucial decision to initiate intravenous infliximab infusions at a dosage of 5 mg/kg at specified intervals. 20,21 The response of the patient to infliximab in this case report was both unique and remarkable. Within the first week of infliximab treatment, the patient experienced a dramatic improvement in neck pain.…”

“…Partial relief was achieved through the administration of meloxicam, an NSAID, and sustained‐release diclofenac sodium capsules. However, the persistence of symptoms prompted a crucial decision to initiate intravenous infliximab infusions at a dosage of 5 mg/kg at specified intervals 20,21 …”

Tofacitinib for Sjögren syndrome with renal tubular acidosis and psoriasis

“…3 Several studies have confirmed that JAK inhibitors have achieved good therapeutic effects in many immune-related skin diseases. 4,5 In summary, we reported a case of primary SS complicated with plaque psoriasis. The patient was admitted due to type I renal…”

JAKi: Can it be used to treat SAPHO syndrome?

“…There are also reports indicating that tofacitinib can improve skin symptoms in patients with AS coexisting with SAPHO syndrome and prevent worsening of thoracolumbar pain after discontinuation of adalimumab 17 . We also have a case report of a patient with coexisting SAPHO syndrome and Takayasu arteritis (TAK), where tofacitinib improved vascular thickness 18 . Recently, a case of a patient who developed recurrent‐relapsing polychondritis (RP) 10 years after being diagnosed with SAPHO syndrome has been reported.…”

“…17 We also have a case report of a patient with coexisting SAPHO syndrome and Takayasu arteritis (TAK), where tofacitinib improved vascular thickness. 18 Recently, a case of a patient who developed recurrent-relapsing polychondritis (RP) 10 years after being diagnosed with SAPHO syndrome has been reported. The patient experienced relief of auricular chondritis with successful treatment with tofacitinib.…”