SAPHO syndrome and pamidronate revisited

Valls-Roc, M.; Sanmartí, M. Àngels Viladés i; Salles, Marina Leão Veloso; Holgado, Susana; Olivé, Alejandro

doi:10.1093/rheumatology/keh466

Cited by 22 publications

(11 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Otherwise, non‐steroidal anti‐inflammatory drugs (NSAIDs), disease‐modifying anti‐rheumatic drugs (DMARDs) (i.e. methotrexate, cyclosporin, sulfasalazine), colchicines, corticosteroids (oral or local injection), and recently bisphosphonates and pamidronates are used for SAPHO syndrome . Bisphosphonates have anti‐osteoclastic effects, and pamidronate has anti‐inflammatory effects by suppressing the production of pro‐inflammatory cytokines .…”

Section: Therapymentioning

confidence: 99%

“…methotrexate, cyclosporin, sulfasalazine), colchicines, corticosteroids (oral or local injection), and recently bisphosphonates and pamidronates are used for SAPHO syndrome. [94][95][96][97][98][99] Bisphosphonates have anti-osteoclastic effects, and pamidronate has anti-inflammatory effects by suppressing the production of pro-inflammatory cytokines. 100 By contrast, the most effective and radical treatment for PAO is focal infection treatment.…”

Section: Therapymentioning

confidence: 99%

See 1 more Smart Citation

Pustulotic arthro‐osteitis associated with palmoplantar pustulosis

Yamamoto

2013

The Journal of Dermatology

View full text Add to dashboard Cite

Palmoplantar pustulosis (PPP) is a chronic inflammatory disorder characterized by sterile pustules predominantly involving the palms and soles of middle-aged women. PPP frequently develops or exacerbates following focal infections, such as tonsillitis, odontogenic infection and sinusitis, either with or without arthralgia and/or extra-palmoplantar lesions. Pustulotic arthro-osteitis (PAO) is a joint comorbidity of PPP, most often affecting the anterior chest wall. PAO is sometimes regarded as the same entity as synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome, and may be a subtype or incomplete type of SAPHO syndrome; however, there are several differences. In Japanese patients, PPP with PAO is frequently seen, whereas SAPHO syndrome in the true meaning is rare. A difference of incidence depending on race suggests that different genetic backgrounds may be responsible for susceptibility to these disorders. Bacterial infection, especially Propionibacterium acnes, is suggested to play an important role in the pathogenesis of SAPHO syndrome. P. acnes is responsible for acne, however, bacterium is unassociated with PPP skin lesions which are characterized by sterile pustules. On the other hand, PAO is frequently triggered by focal infection, and treatment of focal infection results in dramatic effects on the release of joint pain. This paper reviews current insights into the clinicopathophysiology of PAO, and discusses its possible mechanisms in comparison with SAPHO syndrome.

show abstract

Section: Therapymentioning

confidence: 99%

Section: Therapymentioning

confidence: 99%

Pustulotic arthro‐osteitis associated with palmoplantar pustulosis

Yamamoto

2013

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…The main treatment is antibiotics, especially azithromycine 26,40 , and non-steroidal antiinflammatory drugs (NSAIDs) 37 . These treatments only reduce pain 45 and in the case of the 42-year-old patient both resulted in transient relief only. Treatments with calcitonin or bisphosphonates (e.g.…”

Section: Therapy and Clinical Coursementioning

confidence: 99%

“…Most treatment plans suggest conservative pharmacotherapy. pamidronic acid) are mentioned 1,40,45 . Steroids were not effective 40 .…”

Section: Therapy and Clinical Coursementioning

confidence: 99%

“…Treatments with calcitonin or bisphosphonates (e.g. 1,40,45 Surgical interventions, such as decortication of the mandible, are reported with limited, or partially satisfactory, success and should be considered carefully, especially in late disease stages and in younger patients 2,17,25 . These treatments only reduce pain 45 and in the case of the 42-year-old patient both resulted in transient relief only.…”

Section: Therapy and Clinical Coursementioning

confidence: 99%

See 1 more Smart Citation