Santral puberte prekoks tanısında bazal lütenizan hormon düzeyinin yeterliliği

Abstract

The known about this topic In the differentiation of central precocious puberty and premature thelarche, ultrasonography findings, basal and stimulated gonadotropin levels, and basal estradiol levels should be evaluated, as well as clinical findings such as growth velocity and bone age. The gold standard test used to demonstrate activation of the hypothalamo-pituitary-gonadal axis is the gonadotropin-releasing hormone stimulation test. Currently, the efficacy is not clear and standardization has not been performed for any alternative approaches to be used instead of the gonadotropinreleasing hormone stimulation test. Contribution of the study In girls presenting with premature breast development, basal luteinizing hormone level (≥0.65 IU/L) and luteinizing hormone/follicle-stimulating hormone ratio (≥0.25) are sensitive methods that can be used in demonstrating the activation of the hypothalamo-pituitary-gonadal axis and in making a diagnosis of central precocious puberty. Among these methods, the variable that gives the best sensitivity and specificity is the measurement of basal luteinizing hormone (≥0.65 IU/L), which is a sensitive test that can be used as a screening test in the diagnosis of central precocious puberty.