SANTAMARINE: Mechanistic studies on multiple diseases

Abstract

Medicinal plants are vital sources of modern and traditional Chinese medicines. Sesquiterpene lactones (SLs) consist of a large group of plant secondary metabolites and belong to C15 terpenoid group. SLs have shown various biological activities including antitumor and anti‐inflammatory activities. Santamarine (STM), C15H20O3, is a kind of sesquiterpene lactone, whose molecular weight is 248.322 g/mol. Santamarine has been isolated from several plants species and has shown eminent biological activities, such as anticancer activity and anti‐inflammatory activity. In this mini‐review, we summarize the studies on the effects and the mechanisms of STM, and explore the avenues of application.

Targeting Cancer through NF-Kb Pathway with Selected Natural Products (β-Elemene, Puerarin and Gypenosides)

“…It is very obvious that the NF-kB is a candidate for therapeutic resistance in a variety of cancers. NPs possess potent therapeutic activity against different cancers through regulation of NF-kB pathway [6,26].…”

“…Natural products (NPs) are considered more effective and less toxic among all therapies [1,3,4]. The vital source of these natural products is medicinal plants [5,6]. NPs cure cancer via modulation of different molecular pathways, including NF-kB, MEK-ERK, autophagy, PI3K/AKT/mTOR, oxidative stress, inflammation and apoptosis [5].…”

“…Sesquiterpene lactones (SLs) are a group of NPs belong to C15 terpenoids group. These SLs possesses a variety of pharmacological and biological activities including anti-cancer and anti-inflammatory [6].…”

Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis

“…1 , 10 NPs, primarily sourced from medicinal plants, are ideal for cancer treatment because of their low toxicity and high success. 1 , 11 , 12 These NPs cure cancer by regulating different pathways, such as PI3K/AKT/mTOR, NF-kB, autophagy, MEK-ERK, inflammation, oxidative stress, and apoptosis. 11 …”

Molecular mechanisms of anticancer activities of polyphyllin VII

“…Therefore, safe, non-resistant, less toxic, and convenient drugs are urgently required . Natural products good for cancer treatment due to low toxicity and high success , its vital source is medicinal plants Jalal et al, 2020). Medicinal plants are a vital source of natural products (NPs;Jalal et al, 2020) and these NPs cure the cancer through regulation of different pathways, such are PI3K/ AKT/mTOR, NF-kB, autophagy, MEK-ERK, inflammation, oxidative stress, and apoptosis .…”