Sanjad-Sakati Syndrome: Oral Health Care

Hassona, Yazan; Rajab, Lamis D.; Taimeh, Dina; Scully, Crispian

doi:10.1159/000488352

Cited by 6 publications

(11 citation statements)

References 8 publications

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“…Patients having hypoparathyroidism showed decreased mandibular cortical thickness [39]. Sanjad-Sakati syndrome is associated with hypoparathyroidism and micrognathia [40]. The EM group showed small mandibles with a reduced PTH level (Figures 2 and 4A).…”

Section: Discussionmentioning

confidence: 95%

Effects of 4-Hexylresorcinol on Craniofacial Growth in Rats

Lee

Kim

et al. 2021

IJMS

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4-Hexylresorcinol (4HR) has been used as a food additive, however, it has been recently demonstrated as a Class I histone deacetylase inhibitor (HDACi). Unlike other HDACi, 4HR can be taken through foods. Unfortunately, some HDACi have an influence on craniofacial growth, therefore, the purpose of this study was to evaluate the effects of 4HR on craniofacial growth. Saos-2 cells (osteoblast-like cells) were used for the evaluation of HDACi and its associated activities after 4HR administration. For the evaluation of craniofacial growth, 12.8 mg/kg of 4HR was administered weekly to 4 week old rats (male: 10, female: 10) for 12 weeks. Ten rats were used for untreated control (males: 5, females: 5). Body weight was recorded every week. Serum and head samples were collected at 12 weeks after initial administration. Craniofacial growth was evaluated by micro-computerized tomography. Serum was used for ELISA (testosterone and estrogen) and immunoprecipitation high-performance liquid chromatography (IP-HPLC). The administration of 4HR (1–100 μM) showed significant HDACi activity (p < 0.05). Body weight was significantly different in male rats (p < 0.05), and mandibular size was significantly smaller in 4HR-treated male rats with reduced testosterone levels. However, the mandibular size was significantly higher in 4HR treated female rats with increased growth hormone levels. In conclusion, 4HR had HDACi activity in Saos-2 cells. The administration of 4HR on growing rats showed different responses in body weight and mandibular size between sexes.

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Section: Discussionmentioning

confidence: 95%

Effects of 4-Hexylresorcinol on Craniofacial Growth in Rats

Lee

Kim

et al. 2021

IJMS

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“…This rare autosomal syndrome has been also predominantly reported in patients of Arab origin [5]. This may be explained by the norms of consanguineous marriage which are dominant and widespread in these regions, thus resulting in the retention and increased rate of homozygote autosomal recessive genetic disorders in these populations [1].…”

Section: Introductionmentioning

confidence: 93%

“…Sanjad-Sakati syndrome (SSS) is a rare autosomal recessive disorder that may affect both genders. This syndrome known as hypoparathyroidism-retardation-dysmorphism (HRD) syndrome has been described mainly in the Middle East regions with a higher prevalence among Arab population [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…Children suffering from SSS have typical dysmorphic craniofacial features including microcephaly, narrow face, large floppy ears, deep-set eyes, thin lips, depressed nasal bridge, micrognathia, and abnormal dentition [1,[3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…The distinct clinical features of this rare disorder are related to mutations in the gene-encoding tubulin specific chaperone E (TBCE; 604934), located on chromosome 1q42-43 which is listed in Online Mendelian Inheritance in Man (OMIM) #241410 [1,2,8].…”

Section: Introductionmentioning

confidence: 99%

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Dental Management of a Tunisian Child with Sanjad-Sakati Syndrome

Chouchène

Khalifa

Masmoudi

et al. 2022

Case Reports in Dentistry

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Sanjad-Sakati syndrome (SSS) is a rare autosomal recessive congenital disorder. The present case report is aimed at describing the orofacial manifestations and dental management of a 4-year seven-month-old, Tunisian boy with SSS. The patient has typical dysmorphic facial features and growth retardation. Intraoral examination revealed micrognathic mandible and maxilla, an arched palate, and small dental arches with an open bite. All the maxillary and mandibular teeth were decayed due to the poor oral hygiene, plaque accumulation, and enamel hypoplasia. Oral rehabilitation involved pulpotomies and root canal therapies on decayed teeth. Resin composite restorations were performed on maxillary and mandibular incisors, and stainless-steel crowns were placed on maxillary and mandibular first and second primary molars. Dental treatment of children with SSS should improve their quality of life and their general health. Undeveloped dental arches associated with dental anomalies as well as learning deficit make very difficult of the oral rehabilitation of such patients.

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4-Hexylresorcinol as Histone Deacetylase Inhibitor

Kim

2024

Biomedical Application of 4-Hexylresorcinol

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Sanjad-Sakati Syndrome: Oral Health Care

Cited by 6 publications

References 8 publications

Effects of 4-Hexylresorcinol on Craniofacial Growth in Rats

Effects of 4-Hexylresorcinol on Craniofacial Growth in Rats

Dental Management of a Tunisian Child with Sanjad-Sakati Syndrome

4-Hexylresorcinol as Histone Deacetylase Inhibitor

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