Sanionins: Anti‐Inflammatory and Antibacterial Agents with Weak Cytotoxicity from the Antarctic MossSanionia georgico‐uncinata

Abstract

Sanionins A (1) and B (2) were isolated from the moss Sanionia georgico-uncinata, collected on the Antarctic Livingston Island. The compounds 1 and 2 were purified by solvent extraction, silica gel column chromatography, and preparative HPLC, consecutively. The structures of the both compounds were elucidated by 1D and 2D NMR experiments and mass spectrometric investigations. These compounds showed activity against important Gram-positive pathogens, such as mycobacteria, multiresistant staphylococci, and vancomycin resistant enterococci. This activity is combined with antiinflammatoric activity and low cytotoxicity.

Total flavonoid concentrations of bryophytes from Tianmu Mountain, Zhejiang Province (China): Phylogeny and ecological factors

“…Bryophyte flavonoids are of great significance in research on phylogeny and metabolism [ 13 – 14 ]. Extracts from bryophytes which contain flavonoids have been investigated extensively for their potential pharmacological applications: cytotoxic, anticancer and antitumor [ 15 – 17 ], antifungal [ 18 – 19 ], antibacterial [ 20 – 21 ] and antioxidant activities, and their ability to inhibit AChE activity [ 22 ].…”

Pharmacological screening of bryophyte extracts that inhibit growth and induce abnormal phenotypes in human HeLa cancer cells

“…The only reported screening of mosses for antitumor agents was conducted by the National Cancer Institute (NCI) using cytotoxicity assays in the 1980s [8]. To date, very few cytotoxic molecules isolated from mosses have been reported except benzonaphthoxanthenones from Polytrichum species [9–11], cinnamoyl bibenzyls from Polytrichum pallidisetum [11] and Sanionia georgico‐uncinata [12] and maytansine analogues from Claopodium crispifolium [13], Anomodon attenuatus [13], Isothecium subdiversiforme [14] and Thamnobryum sandei [14]. Only maytansine and derivatives were studied for their mechanisms of action and were shown to inhibit microtubule polymerization [15,16].…”

Anti-inflammatory Effects of the Methanol Extract of Polytrichum Commune via NF-κB Inactivation in RAW 264.7 Macrophage Cells

“…Recently various physiological active materials of bryophyte have been reported to possess anti-oxidant (Nimptsch and Pflugmacher, 2008), anti-bacterial and anti-inflammatory effects (Ivanova et al, 2007). Bryophyte Polytrichum commune Hedw (Polytrichaceae) ranges widely in Korea; however, no report has been issued on their anti-inflammatory activity or mode of action.…”