Sandwich-structure hydrogels implement on-demand release of multiple therapeutic drugs for infected wounds

Zheng, Tao; Huang, Jinjian; Jiang, Yungang; Tang, Qin-qing; Liu, Ye; Xu, Ziyan; Wu, Xiuwen; Ren, Jianan

doi:10.1039/c9ra09412a

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…Tao Zheng et al [ 138 ] prepared Rg3-loaded sandwich hydrogel dressings with hydrophilic matrices, such as xanthan gum, hyaluronic acid sodium (HA), and carboxymethyl chitosan (CMCS). The loading amount of Rg3 is 220 μg/mL.…”

Section: Rg3-loaded Wound Dressingmentioning

confidence: 99%

Polymer-Based Wound Dressings Loaded with Ginsenoside Rg3

et al. 2023

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The skin, the largest organ in the human body, mainly plays a protective role. Once damaged, it can lead to acute or chronic wounds. Wound healing involves a series of complex physiological processes that require ideal wound dressings to promote it. The current wound dressings have characteristics such as high porosity and moderate water vapor permeability, but they are limited in antibacterial properties and cannot protect wounds from microbial infections, which can delay wound healing. In addition, several dressings contain antibiotics, which may have bad impacts on patients. Natural active substances have good biocompatibility; for example, ginsenoside Rg3 has anti-inflammatory, antibacterial, antioxidant, and other biological activities, which can effectively promote wound healing. Some researchers have developed various polymer wound dressings loaded with ginsenoside Rg3 that have good biocompatibility and can effectively promote wound healing and reduce scar formation. This article will focus on the application and mechanism of ginsenoside Rg3-loaded dressings in wounds.

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Section: Rg3-loaded Wound Dressingmentioning

confidence: 99%

Polymer-Based Wound Dressings Loaded with Ginsenoside Rg3

et al. 2023

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“…The micro broth dilution method was used to detect the susceptibility of different strains to Ag-PVPNPs and antibiotics. In order to study the relationship between the cytotoxicity of nano silver ion dressings and time, the nano silver ion composite dressings CZ-J1, CZ-J2, CZ-J3, CZ-J4 group samples prepared by the immersion method were selected as the test samples, and the test samples were against L02 cells (22).…”

Section: Drug Sensitivity Testmentioning

confidence: 99%

Teaching Research on Using Nano Silver Ion Dressing in Clinical Nursing of Surgically Infected Wounds

Luo¹,

Li²,

Li³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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In real life, there are few occasions where nanomaterials are exposed alone, and more often they coexist with other chemical substances. This article mainly studies the teaching of using nano-silver dressings in clinical nursing of surgically infected wounds. In this paper, the convenience sampling method is used to select 60 patients with chronic wounds as the research objects. A 160μg/mL nano-silver solution prepared with 10% fetal bovine serum DMEM culture medium was dropped on the copper net, and TEM was used for detection. The nanosilver dispersed in different dispersions was divided into 4mL EP tubes and incubated at 4°C, 25°C and 37°C for 0, 3, 12, 24, and 48 hours, and the sample at different time points were detected by a microplate reader. The maximum UV absorption peak was at 300~700nm wavelength. The micro broth dilution method was used to detect the susceptibility of different strains to Ag-PVPNPs and antibiotics. In order to study the relationship between the cytotoxicity of nano silver ion dressings and time, the nano silver ion composite dressings CZ-J1, CZ-J2, CZ-J3, CZ-J4 group samples prepared by the immersion method were selected as test samples, and the test samples were against L02 cells. At different periods, some cloth samples were taken out for anti-adhesion testing. The SPSS19.0 software was used for statistical analysis of the data, and the measurement data were expressed by the mean and standard deviation, and the homogeneity of variance was tested first. The data shows that when combined with 12.5μg/mL Ag-PVP NPs, 2μg/mL gentamicin can completely inhibit the growth of bacteria compared with 50% inhibition rate when acting alone. The results show that nano-silver activated carbon fiber dressing can effectively promote the healing of pressure sore wounds.

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