Sandwich spatial saturation for neuromelanin-sensitive MRI: Development and multi-center trial

Ji, Sooyeon; Choi, Eun‐Jung; Sohn, Beomseok; Baik, Kyoungwon; Shin, Na‐Young; Moon, Won‐Jin; Park, Seongbeom; Song, Soohwa; Lee, Phil Hyu; Shin, Dong Hoon; Oh, Se‐Hong; Kim, Eung Yeop; Lee, Jong-Ho

doi:10.1016/j.neuroimage.2022.119706

Cited by 2 publications

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recently, fast imaging acquisition methods (≥5 min) have been reported with the use of compressed sensing (CS) and a method of sandwiching the imaging pulses between spatially saturated pulses. 3,4 However, many clinical systems cannot use CS yet. Additionally, most current GRE-based imaging acquisitions are conducted with MT pulses.…”

Section: Introductionmentioning

confidence: 99%

Comparison of 3D Magnetization-transfer- and Spectral-presaturation-with-inversion-recovery-based Neuromelanin Imaging

Kusama,

Kimura,

Yoneyama

et al. 2024

magn reson med sci

View full text Add to dashboard Cite

Neuromelanin is visualized by optimizing the conditions of longitudinal relaxation (T1)-weighted imaging (T1WI). Although it was originally developed in 2D imaging, 3D imaging has been also reported, and T1WI sequences with magnetization transfer (MT) pulses are now widely used in 3D gradient echo (GRE) sequences. In this study, we assert that the use of spectral presaturation with inversion recovery (SPIR) may also be useful as an alternative to MT pulses, and we optimize SPIR and compare it with MT.Methods: Neuromelanin images with MT pulse and SPIR (flip angles [FAs] = 19º, 22º, and 25º) were acquired from 30 healthy volunteers. To achieve the same acquisition time of 5 min, the slab thickness of the MT images was less than 1/3 of those of the SPIR images; the acquisition areas for MT and SPIR were the brainstem and the whole brain, respectively. Visual and quantitative evaluation was performed and compared on the four sequences acquired for the substantia nigra pars compacta (SNc) and the locus coeruleus (LC). For visual assessment, we used the mean score from a 3-point scale by two evaluators. For quantitative evaluation, the contrast ratios of SNc and LC were calculated in comparison with the background tissue signal.Results: In visual assessments, the mean scores of the SPIR FA19º and FA22º images were better than others in the SNc. Regarding LC, the SPIR FA22º image yielded the best mean score. In quantitative evaluations, the MT image was significantly lower than the other three images in SNc. Regarding LC, there were no significant differences among the four acquired images (MT and SPIR FA19º, FA22º, and FA25º).Conclusions: Detection of neuromelanin in SNc and LC was improved by the use of SPIR compared to MT pulse in 3D neuromelanin imaging.

show abstract

Section: Introductionmentioning

confidence: 99%