Sandwich/Sequential but not Concurrent Chemoradiation Therapy is Associated with Overall Survival for Advanced Endometrial Carcinomas

Abstract

V45 for bladder from 110 to 126 cc (mean 117 AE 6.3 cc), and V45 for rectum from 35 to 38 cc (mean 36 AE 1.4 cc). For dataset B, the V45 for bowel space ranged from 109 to 449 cc (mean 237 AE 120 cc), V45 for bladder from 95 to 122 cc (mean 122 AE 9.0 cc), and V45 for rectum from 17 to 19 cc (mean 17.6 AE 0.8 cc). Variations in normalized means of V45 from dataset A were significantly greater for bowel space when compared to bladder (pZ0.02) and rectum (pZ0.01). Similarly, significantly greater variation in V45 was observed for bowel space compared to bladder (pZ0.01) and rectum (p<0.01) for dataset B. Conclusion: Significant variability exists in how the bowel space OAR is practically delineated during treatment planning for gynecologic cancers. These discrepancies may potentially result in misleading radiation dose and volume assessments for the small bowel. The clinical impact of these findings warrant further study.