Sandbank Epitheliopathy of the Conjunctiva (SEC) A New Indicator in Dry Eye Diagnostics Useful for Optimized Ocular Surgery

Setten, Gysbert van

doi:10.21767/2471-8300.100029

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…On the side of the bleb towards the fornices the staining was usually less and had mostly a sandbank epitheliopathy [11,12] like appearance. Such staining occurred mainly when tear fluid insufficiency was simultaneously present.…”

Section: Resultsmentioning

confidence: 99%

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Epitheliopathy of the bleb (EoB) - identifying attrition: A new model for failure of glaucoma surgery

Setten¹

2018

New Front Ophthalmol

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Introduction: Fluorescein staining of the ocular surface is used to detect anomalies and damage of the ocular surface. The intensity of staining and its pattern does reflect underlying pathology and severity. We have recently reported on the presence of sandbank epitheliopathy and its specific staining of the conjunctival surface. As glaucoma surgery is known to alter ocular tissues structures we investigated if it might cause a characteristic footpint at the ocular surface.

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Section: Resultsmentioning

confidence: 99%

“…Slitlamp photography was conducted using a cobalt blue filter and a yellow filter within 30 seconds after application of a standardized amount of fluorescein. The results were compared to the recently described features of anatomical dry eye and sandbank epitheliopathy [11,12]. …”

Section: Methodsmentioning

confidence: 99%

Epitheliopathy of the bleb (EoB) - identifying attrition: A new model for failure of glaucoma surgery

Setten¹

2018

New Front Ophthalmol

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“…Any persisting elevated friction during blinking exercises mechanical stress resulting in epithelial damage. This is visible as corneal and conjunctival staining and lid wiper epitheliopathy, inflammation of the lid rim eventually associated with obstruction of Meibomian gland orifices, and possible changes of ocular surface topography, like lid-parallel conjunctival folds (LIPCOF) or sandbank epitheliopathy [58][59][60]. In fact, only 60 s of eye rubbing are sufficient to cause elevated levels of inflammatory markers like MMP-13, IL-6 and TNF-α in healthy eyes [61].…”

Section: Ocular Surface Homeostasismentioning

confidence: 99%

Why Chain Length of Hyaluronan in Eye Drops Matters

Müller-Lierheim¹

2020

Diagnostics

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The chain length of hyaluronan (HA) determines its physical as well as its physiological properties. Results of clinical research on HA eye drops are not comparable without this parameter. In this article methods for the assessment of the average molecular weight of HA in eye drops and a terminology for molecular weight ranges are proposed. The classification of HA eye drops according to their zero shear viscosity and viscosity at 1000 s−1 shear rate is presented. Based on the gradient of mucin MUC5AC concentration within the mucoaqueous layer of the tear film a hypothesis on the consequences of this gradient on the rheological properties of the tear film is provided. The mucoadhesive properties of HA and their dependence on chain length are explained. The ability of HA to bind to receptors on the ocular epithelial cells, and in particular the potential consequences of the interaction between HA and the receptor HARE, responsible for HA endocytosis by corneal epithelial cells is discussed. The physiological function of HA in the framework of ocular surface homeostasis and wound healing are outlined, and the influence of the chain length of HA on the clinical performance of HA eye drops is illustrated. The use of very high molecular weight HA (hylan A) eye drops as drug vehicle for the next generation of ophthalmic drugs with minimized side effects is proposed and its advantages elucidated. Consequences of the diagnosis and treatment of ocular surface disease are discussed.

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“…The elevated friction, reduced hydration, and increased evaporation rate of mucous-deficient tear film in combination with alterations in the membrane-bound mucins of the ocular surface are likely to be the main causes for lid wiper epitheliopathy, LIPCOF, and sandbank epitheliopathy 22 , 23 , 24 .…”

mentioning

confidence: 99%