Sampling and monitoring in bioprocessing using microtechniques

Gastrock, Gunter; Lemke, Karen; Metze, J.

doi:10.1016/s1389-0352(01)00034-4

Cited by 5 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development of advanced analytical and bioseparation methodologies based on micro-or macroarrays and biosensors is one of the strategic objectives of the so-called postgenomics, but it also has an impact on strategic application fields, such as predictive oncology, diagnostics in the biomedical field, and drug research (Gastrock et al, 2001;Haake et al, 2000;McGlennen, 2001;Rich and Myszka, 2001;Van Regenmortel, 2001). Comprehensive lists of recently published articles describing works employing commercial biosensors and emerging applications in areas of drug discovery, clinical support, food and environment monitoring, and cell membrane biology are available (Rich and Myszka, 2001).…”

Section: Introductionmentioning

confidence: 99%

Levitation and movement of human tumor cells using a printed circuit board device based on software‐controlled dielectrophoresis

Altomare¹,

Borgatti²,

Medoro³

et al. 2003

Biotech & Bioengineering

View full text Add to dashboard Cite

In this study we describe an original, efficient, and innovative printed circuit board (PCB) device able to generate dielectrophoresis-based, software-controlled cages that can be moved to any place inside a microchamber. Depending on their dielectrophoretic properties, eukaryotic cells can be "entrapped" in cages and moved under software control. The main conclusion gathered from the experimental data reported is that the PCB device based on dielectrophoresis permits levitation and movement of different tumor cells at different dielectrophoresis conditions. The results presented herein are therefore the basis for experiments aimed at forced interactions or separation of eukaryotic cells using "lab-on-a-chip." In fact, because many cages can be controlled at the same time, and two or more cages can be forced to share the same or a different location, it is possible, in principle, either to bring in contact cells of a differing histotype or to separate them.

show abstract

Section: Introductionmentioning

confidence: 99%

Levitation and movement of human tumor cells using a printed circuit board device based on software‐controlled dielectrophoresis

Altomare¹,

Borgatti²,

Medoro³

et al. 2003

Biotech & Bioengineering

View full text Add to dashboard Cite

show abstract

The Choice of Suitable Online Analytical Techniques and Data Processing for Monitoring of Bioprocesses

Marison

Hennessy

Foley

et al. 2012

Advances in Biochemical Engineering/Biotechnology

View full text Add to dashboard Cite

With increasing pressure from regulatory authorities on industry to develop processes embracing process analytical technology (PAT) initiatives, there is a growing demand to establish reliable tools and systems capable of meeting this need. With regard to monitoring and control of bioprocesses, this need translates to a search for robust instrumentation capable of monitoring the critical process parameters in real time. The application of such technologies at all stages of the process, from the initial R&D phase to process optimisation and production, enhances process understanding and paves the way for the development of control platforms. An examination of the PAT concept and selected tools (NIR, MIR, Raman, dielectric spectroscopy and calorimetry) are presented here. A description of each tool is given, with particular emphasis on the nature of the signal produced and how these relate to measurements of biomass, metabolites and product. A description of the signal processing that is necessary to gain meaningful results from the different tools is also given, together with online data reconciliation techniques based on mass and energy balances. Many techniques such as those based on vibrational spectroscopy are of particular interest, since they are capable of monitoring several critical process parameters which are typically controlled in a bioprocess. A window of application for each of the techniques, when used in the area of bioprocessing, is suggested based on their uses and inherent limitations.

show abstract

Bulk Hybrid Liquid Membrane with Organic Water-Immiscible Carriers

Kislik

2010

Liquid Membranes

View full text Add to dashboard Cite

Sampling and monitoring in bioprocessing using microtechniques

Cited by 5 publications

References 26 publications

Levitation and movement of human tumor cells using a printed circuit board device based on software‐controlled dielectrophoresis

Levitation and movement of human tumor cells using a printed circuit board device based on software‐controlled dielectrophoresis

The Choice of Suitable Online Analytical Techniques and Data Processing for Monitoring of Bioprocesses

Bulk Hybrid Liquid Membrane with Organic Water-Immiscible Carriers

Contact Info

Product

Resources

About