Samp lyase and AMP deaminase activity in rat parenchymal and kupffer cells in hepatocarcinogenesis

Smith, Larry; Lewis, Eliza L; Morrical, Scott W.; Butler, Marie

doi:10.1016/0020-711x(84)90115-0

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…A quite opposite may be true in the case of AMP-deaminase isolated from cirrhotic liver [ 53 ]. Here, diminished resistance of the enzyme for intracellular proteolysis has been suggested as a probable factor diminishing activity of AMP-deaminase [ 54 ]. However, no evidence has been reported on the role and mechanism of ABCC13 gene in cancer.…”

Section: Discussionmentioning

confidence: 99%

Identification of four novel hub genes as monitoring biomarkers for colorectal cancer

et al. 2022

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Background It must be admitted that the incidence of colorectal cancer (CRC) was on the rise all over the world, but the related treatment had not caught up. Further research on the underlying pathogenesis of CRC was conducive to improving the survival status of current CRC patients. Methods Differentially expressed genes (DEGs) screening were conducted based on “limma” and “RobustRankAggreg” package of R software. Weighted gene co-expression network analysis (WGCNA) was performed in the integrated DEGs that from The Cancer Genome Atlas (TCGA), and all samples of validation were from Gene Expression Omnlbus (GEO) dataset. Results The terms obtained in the functional annotation for primary DEGs indicated that they were associated with CRC. The MEyellow stand out whereby showed the significant correlation with clinical feature (disease), and 4 hub genes, including ABCC13, AMPD1, SCNN1B and TMIGD1, were identified in yellow module. Nine datasets from Gene Expression Omnibus database confirmed these four genes were significantly down-regulated and the survival estimates for the low-expression group of these genes were lower than for the high-expression group in Kaplan-Meier survival analysis section. MEXPRESS suggested that down-regulation of some top hub genes may be caused by hypermethylation. Receiver operating characteristic curves indicated that these genes had certain diagnostic efficacy. Moreover, tumor-infiltrating immune cells and gene set enrichment analysis for hub genes suggested that there were some associations between these genes and the pathogenesis of CRC. Conclusion This study identified modules that were significantly associated with CRC, four novel hub genes, and further analysis of these genes. This may provide a little new insights and directions into the potential pathogenesis of CRC.

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Section: Discussionmentioning

confidence: 99%

Identification of four novel hub genes as monitoring biomarkers for colorectal cancer

et al. 2022

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RETRACTED ARTICLE: Expression patterns of AMP-deaminase isozymes in human hepatocellular carcinoma (HCC)

Szydłowska

Roszkowska

2008

Mol Cell Biochem

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Expression level of AMPD gene family in the tumorous fragment (HCC tumor) of neoplastic liver did not differ substantially from that found in the nontumorous (cirrhotic) fragment of the organ. In this case the expression of AMPD2 gene was prevailing. AMPD2 was the main isoform of AMP-deaminase identified in two liver fragments compared. This is a first report evidencing the pattern of AMPD genes expression in neoplastic human liver.

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AMP deaminase and adenosine deaminase activities in liver and brain regions in acute ammonia intoxication and subacute toxic hepatitis

Kaminsky

Kosenko

2010

Brain Research

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Samp lyase and AMP deaminase activity in rat parenchymal and kupffer cells in hepatocarcinogenesis

Cited by 4 publications

References 17 publications

Identification of four novel hub genes as monitoring biomarkers for colorectal cancer

Identification of four novel hub genes as monitoring biomarkers for colorectal cancer

RETRACTED ARTICLE: Expression patterns of AMP-deaminase isozymes in human hepatocellular carcinoma (HCC)

AMP deaminase and adenosine deaminase activities in liver and brain regions in acute ammonia intoxication and subacute toxic hepatitis

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