Same Intervention–Different Reorganization

Carey, Leeanne M.; Abbott, David F.; Lamp, Gemma; Puce, Aina; Seitz, Rüdiger J.; Donnan, Geoffrey A.

doi:10.1177/1545968316653836

Cited by 27 publications

(24 citation statements)

References 55 publications

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“…At 14 days after stroke, our interregional and node degree analysis revealed that, compared to STD, EE increased RS-FC among these particular networks relevant for recovery of proprioception ( Ben-Shabat et al, 2015 ) and touch ( Carey et al, 2016 ) in stroke patients. We therefore propose that RS-FC changes observed in the secondary motor cortices, contralesional posterior parietal and retrosplenial regions could be instrumental in the marked improvements in tactile-proprioceptive function observed after stroke in the EE group.…”

Section: Discussionmentioning

confidence: 78%

Multisensory stimulation improves functional recovery and resting-state functional connectivity in the mouse brain after stroke

Hakon

Quattromani

Sjölund

et al. 2018

NeuroImage: Clinical

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Stroke causes direct structural damage to local brain networks and indirect functional damage to distant brain regions. Neuroplasticity after stroke involves molecular changes within perilesional tissue that can be influenced by regions functionally connected to the site of injury. Spontaneous functional recovery can be enhanced by rehabilitative strategies, which provides experience-driven cell signaling in the brain that enhances plasticity. Functional neuroimaging in humans and rodents has shown that spontaneous recovery of sensorimotor function after stroke is associated with changes in resting-state functional connectivity (RS-FC) within and across brain networks. At the molecular level, GABAergic inhibitory interneurons can modulate brain plasticity in peri-infarct and remote brain regions. Among this cell-type, a decrease in parvalbumin (PV)-immunoreactivity has been associated with improved behavioral outcome. Subjecting rodents to multisensory stimulation through exposure to an enriched environment (EE) enhances brain plasticity and recovery of function after stroke. Yet, how multisensory stimulation relates to RS-FC has not been determined. In this study, we investigated the effect of EE on recovery of RS-FC and behavior in mice after stroke, and if EE-related changes in RS-FC were associated with levels of PV-expressing neurons. Photothrombotic stroke was induced in the sensorimotor cortex. Beginning 2 days after stroke, mice were housed in either standard environment (STD) or EE for 12 days. Housing in EE significantly improved lost tactile-proprioceptive function compared to mice housed in STD environment. RS-FC in the mouse was measured by optical intrinsic signal imaging 14 days after stroke or sham surgery. Stroke induced a marked reduction in RS-FC within several perilesional and remote brain regions. EE partially restored interhemispheric homotopic RS-FC between spared motor regions, particularly posterior secondary motor. Compared to mice housed in STD cages, EE exposure lead to increased RS-FC between posterior secondary motor regions and contralesional posterior parietal and retrosplenial regions. The increased regional RS-FC observed in EE mice after stroke was significantly correlated with decreased PV-immunoreactivity in the contralesional posterior motor region. In conclusion, experimental stroke and subsequent housing in EE induces dynamic changes in RS-FC in the mouse brain. Multisensory stimulation associated with EE enhances RS-FC among distinct brain regions relevant for recovery of sensorimotor function and controlled movements that may involve PV/GABA interneurons. Our results indicate that targeting neural circuitry involving spared motor regions across hemispheres by neuromodulation and multimodal sensory stimulation could improve rehabilitation after stroke.

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Section: Discussionmentioning

confidence: 78%

Multisensory stimulation improves functional recovery and resting-state functional connectivity in the mouse brain after stroke

Hakon

Quattromani

Sjölund

et al. 2018

NeuroImage: Clinical

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“…These reductions could be indicative of network-level inefficiencies important for segregation. For example, in mice we have recently shown (59) that improved tactile proprioception after stroke was associated with increased node degree in motor, somatosensory, and parietal cortices -all regions relevant for processing proprioception and touch (60). In the present study, reduced within-network connectivity (i.e., node degree) combined with poorer integration across networks (i.e., reduced anticorrelations) could impair multidomain behavioral output, as demonstrated by poorer social and emotional performance of the OXT-treated group.…”

Section: Discussionmentioning

confidence: 99%

In utero exposure to transient ischemia-hypoxemia promotes long-term neurodevelopmental abnormalities in male rat offspring

Palanisamy¹,

Giri²,

Jiang³

et al. 2020

JCI Insight

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“…Age-related changes in activation have been seen, with decreased activation in S2 with tactile stimulation evident in elderly participants who are known to experience behavioral decline in somatosensory thresholds (54). The relationship of bilateral S2 with tactile sensation must also be considered in fields such as stroke research, where the location of the lesion has been demonstrated to impact both the type of somatosensory dysfunction (107), and also the ability to recover after stroke (108). Our finding of overlap in activation of right secondary somatosensory region for RH and LH tactile stimulation, may have particular relevance after stroke.…”

Section: Discussionmentioning

confidence: 99%

Activation of Bilateral Secondary Somatosensory Cortex With Right Hand Touch Stimulation: A Meta-Analysis of Functional Neuroimaging Studies

et al. 2019

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Background: Brain regions involved in processing somatosensory information have been well documented through lesion, post-mortem, animal, and more recently, structural and functional neuroimaging studies. Functional neuroimaging studies characterize brain activation related to somatosensory processing; yet a meta-analysis synthesis of these findings is currently lacking and in-depth knowledge of the regions involved in somatosensory-related tasks may also be confounded by motor influences.Objectives: Our Activation Likelihood Estimate (ALE) meta-analysis sought to quantify brain regions that are involved in the tactile processing of the right (RH) and left hands (LH) separately, with the exclusion of motor related activity.Methods: The majority of studies (n = 41) measured activation associated with RH tactile stimulation. RH activation studies were grouped into those which conducted whole-brain analyses (n = 29) and those which examined specific regions of interest (ROI; n = 12). Few studies examined LH activation, though all were whole-brain studies (N = 7).Results: Meta-analysis of brain activation associated with RH tactile stimulation (whole-brain studies) revealed large clusters of activation in the left primary somatosensory cortex (S1) and bilaterally in the secondary somatosensory cortex (S2; including parietal operculum) and supramarginal gyrus (SMG), as well as the left anterior cingulate. Comparison between findings from RH whole-brain and ROI studies revealed activation as expected, but restricted primarily to S1 and S2 regions. Further, preliminary analyses of LH stimulation studies only, revealed two small clusters within the right S1 and S2 regions, likely limited due to the small number of studies. Contrast analyses revealed the one area of overlap for RH and LH, was right secondary somatosensory region.Conclusions: Findings from the whole-brain meta-analysis of right hand tactile stimulation emphasize the importance of taking into consideration bilateral activation, particularly in secondary somatosensory cortex. Further, the right parietal operculum/S2 region was commonly activated for right and left hand tactile stimulation, suggesting a lateralized pattern of somatosensory activation in right secondary somatosensory region. Implications for further research and for possible differences in right and left hemispheric stroke lesions are discussed.

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Same Intervention–Different Reorganization

Abstract: Different patterns of change in activation are evident following touch discrimination training with thalamic/capsular lesions compared with S1/S2 cortical somatosensory lesions, despite common training and similar improvement.

Cited by 27 publications

References 55 publications

Multisensory stimulation improves functional recovery and resting-state functional connectivity in the mouse brain after stroke

Multisensory stimulation improves functional recovery and resting-state functional connectivity in the mouse brain after stroke

In utero exposure to transient ischemia-hypoxemia promotes long-term neurodevelopmental abnormalities in male rat offspring

Activation of Bilateral Secondary Somatosensory Cortex With Right Hand Touch Stimulation: A Meta-Analysis of Functional Neuroimaging Studies

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