Samarium-153 for intravascular irradiation therapy with liquid-filled balloons to prevent restenosis: acute and long-term results in a hypercholesterolemic rabbit restenosis model

Moura, Álvaro Vieira; Yamada, Ana Lúcia Miluzzi; Hauer, Dario; Perussolo, Rita; Munhoz, Claudia; Canova, Rodrigo; Oliva, Lubomira; Précoma, Dalton Bertolin

doi:10.1016/s1522-1865(00)00077-9

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…Methods for the delivery of the radiation source to the target site vary; a carrier wire inserted through a catheter or a fluid source injected into an angioplasty balloon are mostly used (10,11). The carrier wire requires proper placement in the vessel lumen (usually with a centering balloon) so that inordinate radiation exposure does not occur on one wall, while the opposite wall receives a minimal or subtherapeutic dose.…”

Section: Brachytherapy: Hot or Notmentioning

confidence: 99%

Brachytherapy: Hot or Not

McCowan¹,

Baker²

2002

Radiology

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Section: Brachytherapy: Hot or Notmentioning

confidence: 99%

Brachytherapy: Hot or Not

McCowan¹,

Baker²

2002

Radiology

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“…Delivery of local radiation causes phenotypic changes that prevent cell reproduction by deoxyribonucleic acid (DNA), inhibiting smooth muscle cell (SMC) proliferation and migration and thus decreasing the degree of neointimal hyperplasia 8 . Our group showed that brachytherapy with samarium-153, used for the first time, at a dose of 15 Gy effectively inhibits neointimal proliferation 9 . Several studies, comparing higher doses, have demonstrated better results in NIP inhibition.…”

mentioning

confidence: 99%

Radiolesão vascular como efeito deletério da braquiterapia intra-arterial com dose elevada de Samário-153 em coelhos hipercolesterolêmicos

Précoma¹,

Noronha²,

Moura³

et al. 2006

Arq. Bras. Cardiol.

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objective: This study was designed to evaluate vascular morphological and morphometric changes induced by brachytherapy with samarium-153 (Sm-153) at high doses in hypercholesterolemic rabbits.Methods: Forty-three New Zealand White hypercholesterolemic rabbits were analyzed, and the total of 86 iliac arteries underwent balloon angioplasty injury. The rabbits were divided into three different groups: two irradiation groups (IG) assigned to 15 Gy (n=14) and 60 Gy (n=36) irradiation doses, respectively, and a control group (n = 36). Histomorphometric and qualitative histological analyses were performed for tissue evaluation.results: Significant reductions were found in neointimal proliferation (NIP) (p< 0.0001), media area (MA) (p<0.0001) and percent stenosis (p<0.0001) in the 15-Gy IG, compared to the other groups. The 60-Gy IG had the higher rate of NIP, increase in media and vessel areas (VA) and percent stenosis. The 60-Gy IG also showed the greatest number of xanthomatous cells (60-Gy IG: 86.11% and 15-Gy IG: 14.29%, p<0.0001) and the highest amount of hyaline amorphous tissue (60-Gy IG:58.33% and 15-Gy IG:0%, p=0.0001) and vascular proliferation (60-Gy IG:30.56% and 15-Gy IG:0%, p=0.0221). No statistically significant differences were found among groups concerning other tissue analyses. conclusion:The high-dose irradiation of 60 Gy resulted in intense cell proliferation considered vascular radiolesion, unlike the 15-Gy dose, which was associated with an excellent inhibition of neointimal proliferation.

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Inhibition of Arterial Restenosis Following Balloon Angioplasty

Knapp

Dash

2016

Radiopharmaceuticals for Therapy

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Samarium-153 for intravascular irradiation therapy with liquid-filled balloons to prevent restenosis: acute and long-term results in a hypercholesterolemic rabbit restenosis model

Cited by 5 publications

References 21 publications

Brachytherapy: Hot or Not

Brachytherapy: Hot or Not

Radiolesão vascular como efeito deletério da braquiterapia intra-arterial com dose elevada de Samário-153 em coelhos hipercolesterolêmicos

Inhibition of Arterial Restenosis Following Balloon Angioplasty

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