Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats

Zhang, Ning; Hu, Yan; Ding, Chunchun; Zeng, Wenjing; Shan, Wen; Fan, Hui; Zhao, Yan; Shi, Xue; Gao, Lili; Xu, Ting; Wang, Ruiwen; Gao, Dongyan; Yao, Jihong

doi:10.1016/j.toxlet.2016.12.010

Cited by 53 publications

(35 citation statements)

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“…[25][26][27][28] We have demonstrated that SIRT1 participates in the alleviation of chronic alcoholic liver injury by preventing fat accumulation, decreasing ROS production, and reducing inammation and cell death. 29,30 Interestingly, SIRT1 deacetylates a number of transcription factors, including histone H4, NF-kB, and p53. 31,32 The SIRT1/FoxO pathway accelerates AV development, augments autolysosome formation, and further stimulates autophagy ux.…”

Section: Introductionmentioning

confidence: 99%

Promotion of autophagosome–lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Promotion of autophagosome–lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease

et al. 2018

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“…Although Sal B has been reported a variety of bene cial metabolic effects including ameliorated the histopathological alterations of pancreas, increased muscle glycogen content, increased p-AMPK protein expression in skeletal muscle and liver; increased protein expressions of PPARαand p-ACC in liver. [17,18] Our study showed that Sal B reduced intracellular accumulation of LDs and TG level whereas stimulated autophagosome formation by increasing expression of autophagosome formation marker LC3 II and decreasing autophagy substrates marker p62 expression in hepatocytes. Meanwhile, Beclin-1, another aytophagy biomarker which mainly activated autophagy by formation of class III PI3-kinase complex to stimulate ATG proteins, was found signi cantly higher expression in Sal B treated hepatocytes.…”

Section: Discussionmentioning

confidence: 66%

“…[13][14][15][16] In hepatocytes, Sal B has been reported a strong ability to protect cells from injury induced by oxidative stress, in ammation and enhance hepatic differentiation. [17][18][19] However, the effect of Sal B on improving hepatic lipid disorder is rarely reported. In this study, we interestingly found that Sal B could stimulated hepatic autophagy while reduced lipid accumulation in hepatocyte, which indicated a possible mechanism for Sal B improved lipid disorder and contributed to metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Salvianolic acid B ameliorates hepatocyte lipid droplet accumulation via stimulation of autophagy

Shi

Yuan

Yan

et al. 2020

Preprint

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Salvianolic acid B (Sal B) the most abundant bioactive member in Salvia miltiorrhiza and has been reported lots of benefits on the treatment of cardio-cerebral vascular diseases and metabolic diseases. Lipid droplets are dynamic organelles, excessive lipid droplets accumulation in liver caused fatty liver disease. In this study, we are interested in the effect of Sal B on hepatic lipid accumulation and its possible mechanism. We found Sal B treatment significantly decreased lipid accumulation and TG level in primary hepatocytes. Meanwhile, we discovered Sal B significantly stimulated hepatic autophagy. Then we used autophagy inhibitor 3-MA and reveled that Sal B showed little effect on improving hepatic lipid accumulation when autophagy was inhibited, which indicated Sal B reduced cellular lipid accumulation through activating autophagy. This study demonstrates Sal B ameliorate hepatic lipid accumulation through activation of autophagy. These findings contribute to its benefit on liver disease related to hepatic lipid accumulation and hepatic autophagy.

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“…It has been cultivated in East Asian countries including China and Korea [2]. Its bioactivities such as antioxidant, antibacterial, antiinflammatory, antitumor, and whitening effects and use in healthpromoting foods have been investigated [3][4][5][6]. Moreover, its stability has been investigated [7].…”

Section: Introductionmentioning

confidence: 99%

Marker compound contents and antioxidant capacities of the taproot and lateral root of Danshen (Salvia miltiorrhizaRadix)

Seong

Chung

2020

JABC

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In this study, the marker compound contents of both the taproot and lateral root of Danshen (Salvia miltiorrhiza Radix), which is cultivated in Korea, were investigated. The salvianolic acid B content was the highest in the taproot (5.17-6.75%) and lateral root (3.99-5.69%). The cryptotanshinone, tanshinone I, and tanshinone IIA contents were higher in the lateral root than in the taproot of Danshen (p <0.05). Principal component analysis results revealed that the taproot was correlated to the salvianic acid A, rosmarinic acid, salvianolic acid B, and salvianolic acid A contents, whereas the lateral root was correlated to the cryptotanshinone, tanshinone I, and tanshinone IIA contents. The total phenolic content and total flavonoid content of the taproot were higher than those of the lateral root (p <0.05); however, the antioxidant activities of the taproot and lateral root of Danshen were similar. The salvianolic acid B content was correlated to the TPC of the taproot (r=0.748) and the 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid radical scavenging activity of the lateral root (r=0.847). This study could provide useful information for the classification of Danshen as a herbal medicinal product.

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Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats

Cited by 53 publications

References 47 publications

Promotion of autophagosome–lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease

Promotion of autophagosome–lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease

Salvianolic acid B ameliorates hepatocyte lipid droplet accumulation via stimulation of autophagy

Marker compound contents and antioxidant capacities of the taproot and lateral root of Danshen (Salvia miltiorrhizaRadix)

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