Salvianolic acid B as an anti-emphysema agent II: In vivo reversal activities in two rat models of emphysema

Dhapare, Sneha; Li, Hua; Sakagami, Masahiro

doi:10.1016/j.pupt.2018.09.002

Cited by 4 publications

(5 citation statements)

References 34 publications

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“…In CSE and porcine pancreatic elastase (PPE)-induced animal models, spray instillations with salvianolic acid B significantly improved the bioavailability about 30∼100 fold over oral administration. The anti-emphysema effects of salvianolic acid B can reduce CSE-induced apoptosis and lipid peroxidation, elevate phosphor-signal transducer and activator of transcription 3 and vascular endothelial growth factor (VEGF) expression, and stimulate lung cell proliferation to enable the reversal of alveolar structural destruction in vivo [98]. CSE may cause inflammation and increase the tissue oxidative stress that leads to decreased elastin formation of fibroblasts by inhibiting the enzyme activity of lysyl oxidase [99].…”

Section: Polyphenols Treatment Via Inflammasome In a Cigarette Smokin...mentioning

confidence: 99%

Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

Fu¹,

Kang²,

Yan³

et al. 2022

Eur Respir Rev

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COPD is predicted to become the third leading cause of morbidity and mortality worldwide by 2030. Cigarette smoking (active or passive) is one of its chief causes, with about 20% of cigarette smokers developing COPD from cigarette smoke (CS)-induced irreversible damage and sustained inflammation of the airway epithelium. Inflammasome activation leads to the cleavage of pro-interleukin (IL)-1β and pro-IL-18, along with the release of pro-inflammatory cytokines via gasdermin D N-terminal fragment membrane pores, which further triggers acute phase pro-inflammatory responses and concurrent pyroptosis. There is currently intense interest in the role of nucleotide-binding oligomerisation domain-like receptor family, pyrin domain containing protein-3 inflammasomes in chronic inflammatory lung diseases such as COPD and their potential for therapeutic targeting. Phytochemicals including polyphenols and flavonoids have phyto-medicinal benefits in CS-COPD. Here, we review published articles from the last decade regarding the known associations between inflammasome-mediated responses and ameliorations in pre-clinical manifestations of CS-COPD via polyphenol and flavonoid treatment, with a focus on the underlying mechanistic insights. This article will potentially assist the development of drugs for the prevention and therapy of COPD, particularly in cigarette smokers.

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Section: Polyphenols Treatment Via Inflammasome In a Cigarette Smokin...mentioning

confidence: 99%

Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

Fu¹,

Kang²,

Yan³

et al. 2022

Eur Respir Rev

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“…Moreover, the prescription of exercise-based rehabilitation programs in the clinical practice has grown lately. The mentioned programs are considered a safe intervention [18] to enhance endogenous antioxidant systems through sirtuin 1 (SIRT1) activation [19], among other beneficial effects; however, exogenous antioxidant supplementation may be a useful complementary therapy in patients with diseases associated with oxidative stress [20].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of a Cocoa-Enriched Diet on Oxidative Stress Induced by Intensive Acute Exercise in Rats

et al. 2022

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Intensive acute exercise can induce oxidative stress, leading to muscle damage and immune function impairment. Cocoa diet could prevent this oxidative stress and its consequences on immunity. Our aim was to assess the effect of a cocoa-enriched diet on the reactive oxygen species (ROS) production by peritoneal macrophages, blood immunoglobulin (Ig) levels, leukocyte counts, and the physical performance of rats submitted to an intensive acute exercise, as well as to elucidate the involvement of cocoa fiber in such effects. For this purpose, Wistar rats were fed either a standard diet, i.e., a diet containing 10% cocoa (C10), or a diet containing 5% cocoa fiber (CF) for 25 days. Then, half of the rats of each diet ran on a treadmill until exhaustion, and 16 h later, the samples were obtained. Both C10 and CF diets significantly prevented the increase in ROS production. However, neither the cocoa diet or the cocoa fiber-enriched diet prevented the decrease in serum IgG induced by acute exercise. Therefore, although the cocoa-enriched diet was able to prevent the excessive oxidative stress induced by intensive exercise, this was not enough to avoid the immune function impairment due to exercise.

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“…60 Salvianolic acid b has been investigated as an antiemphysema agent with the ability to reverse alveolar structural damage/loss and inhibit induced lung cell death through JAK2/STAT3/VEGF-dependent stimulation of lung cell proliferation and migration. 61,62 In conclusion, by combining network pharmacology with Affymetrix arrays, we found that XBJ may modulate the FoxO signaling pathway by regulating EGFR, STAT3, AKT1, and CCND1. Furthermore, the anti-inflammatory and antioxidative effects of XBJ are through the PI3K/Akt/FoxO axis combined with MMP9, AR, ESR1, and PTGS2 to regulate other signaling pathways.…”

Section: Discussionmentioning

confidence: 77%

“…60 Salvianolic acid b has been investigated as an anti-emphysema agent with the ability to reverse alveolar structural damage/loss and inhibit induced lung cell death through JAK2/STAT3/VEGF-dependent stimulation of lung cell proliferation and migration. 61,62…”

Section: Discussionmentioning

confidence: 99%

Unraveling the Molecular Mechanism of Xuebijing Injection in the Treatment of Chronic Obstructive Pulmonary Disease by Combining Network Pharmacology and Affymetrix Array

Lin

Zhang

et al. 2022

Natural Product Communications

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Xuebijing injection (XBJ), one of the classical prescriptions for treating inflammation-related diseases, has been used to chronic obstructive pulmonary disease (COPD) in clinical practice. However, its molecular mechanism is still unclear. Network pharmacology combined with Affymetrix arrays and molecular docking techniques were applied to explore the molecular mechanism of XBJ for COPD. Predictive analysis of 728 active compounds in XBJ and 6 sets of Affymetrix arrays expression data resulted in 106 potential therapeutic targets. Next, based on the active compound-co-target network topology analysis, most of these targets were found to be modulated by quercetin, myricetin, and ellagic acid. Furthermore, protein–protein interaction (PPI) analysis revealed that the key targets may be EGFR, STAT3, AKT1, CCND1, MMP9, AR, ESR1, and PTGS2. Then, by constructing a component-target-pathway network, we found that XBJ was a multi-pathway, multi-target, multi-compound synergistic therapy for COPD, and four key targets were involved in the FoxO signaling pathway. Luteolin and salvianolic acid b had the optimal binding ability to several key proteins. Therefore, we hypothesize that quercetin, myricetin, ellagic acid, luteolin, and salvianolic acid b mainly contribute to the therapeutic effect of XBJ on COPD by modulating the FoxO signaling pathway by regulating EGFR, STAT3, AKT1, and CCND1. XBJ exerts anti-inflammatory and antioxidative stress effects through the PI3K/Akt/FoxO axis combined with MMP9, AR, ESR1, and PTGS2 to regulate other signaling pathways.

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Salvianolic acid B as an anti-emphysema agent II: In vivo reversal activities in two rat models of emphysema

Cited by 4 publications

References 34 publications

Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

Protective Effect of a Cocoa-Enriched Diet on Oxidative Stress Induced by Intensive Acute Exercise in Rats

Unraveling the Molecular Mechanism of Xuebijing Injection in the Treatment of Chronic Obstructive Pulmonary Disease by Combining Network Pharmacology and Affymetrix Array

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