Salvia miltiorrhiza polysaccharides alleviates florfenicol induced kidney injury in chicks via inhibiting oxidative stress and apoptosis

Xiao, Wang; Liu, Wei; Jin, Guozhong; Wu, Zhanjun; Zhang, Di; Bao, Yongzhan; Shi, Wei

doi:10.1016/j.ecoenv.2022.113339

Cited by 11 publications

(7 citation statements)

References 40 publications

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“…Animals experiments have demonstrated that NPs from herbs could regulate Nrf2 antioxidant pathway for liver protection ( 14 , 36 , 41 , 54 , 57 , 67 , 116 , 120 , 147 – 153 ), kidney protection ( 21 , 59 , 154 – 157 ), lung protection ( 20 , 158 ), neuroprotection ( 22 , 121 ), cardioprotection ( 124 , 159 ), gastrointestinal protection ( 16 , 40 , 48 , 127 , 128 , 160 , 161 ), anti-oxidation ( 15 , 47 , 162 – 164 ), anti-diabetic ( 56 , 58 , 135 , 146 , 165 , 166 ), anti-aging ( 18 , 68 , 84 , 167 ), anti-inflammation ( 23 ), anti-depression ( 25 ), anti-cancer ( 168 ), and improving reproductive function ( 169 , 170 ), as implied in Table 1 .…”

Section: Regulation Of Nps On Nrf2 Antioxidant Pathway For Health-pro...mentioning

confidence: 99%

“…Natural polysaccharides from herbs exerted liver protection against DSS- ( 67 ), acetaminophen- ( 57 , 147 ), tilmicosin- ( 149 ), CCl 4 - ( 116 , 150 ), ethanol- ( 36 , 54 , 148 ), isoniazid + rifampicin- ( 151 ), methionine and choline deficient diet- ( 152 ), mixture of Cd + Cr + Pb + Mn + Zn + Cu- ( 14 ), LPS- ( 153 ), high-fat diet- ( 41 ), and 5-Fu-induced ( 120 ) mice or rats, through increasing mRNA and protein expressions of Nrf2, nuclear Nrf2, NQO1, GCLC, GCLM, Cu/Zn-SOD, SOD1, and GPX1 in liver tissues, modulating protein and/or mRNA expressions of Keap1 and HO-1, and decreasing protein and/or mRNA expressions of cytosol Keap1, CAT, cytosol Nrf2, p67phox, p47phox, and p22phox in liver tissues. NPs from herbs exhibited kidney protection on LPS- ( 154 , 155 ), lead- ( 156 ), florfenicol- ( 21 ), cadmium- ( 59 ), and STZ-induced ( 157 ) mice, rats or chicks via elevating mRNA and protein expressions of HO-1 and NQO1, regulating Nrf2 expression, and down-regulating mRNA and protein expressions of Keap1 and PGC-1α in kidney tissues. Those from herbs showed lung protection hyperoxia- ( 158 ) and DSS-induced ( 20 ) mice by enhancing activities and/or protein expressions of Nrf2, cytosol Nrf2, nuclear Nrf2, HO-1, and NQO1 in lung tissues as well as protein expressions of Nrf2 in PMVECs isolated from lung, and reducing protein expression of Keap1 in lung tissues.…”

Section: Regulation Of Nps On Nrf2 Antioxidant Pathway For Health-pro...mentioning

confidence: 99%

“…Polysaccharides from natural resources (NPs) have been reported to play key roles in regulating excessive oxidative stress ( 13 ). In the past few decades, regulations of NPs on Nrf2 antioxidant pathway have been extensively studied in their health-promoting effects, such as liver protection ( 14 ), antioxidant ( 15 ), gastrointestinal protection ( 16 ), anti-diabetic ( 17 ), anti-aging ( 18 ), cardioprotection ( 19 ), lung protection ( 20 ), kidney protection ( 21 ), neuroprotection ( 22 ), anti-inflammation ( 23 ), immunomodulation ( 24 ), anti-depression ( 25 ), anti-cancer ( 26 ), improving reproductive function ( 27 ), anti-radiation ( 28 ), and anti-atherosclerosis ( 29 ). However, the information concerning regulation of NPs on Nrf2 antioxidant pathway is scattered, and NPs show different regulatory behaviors in their different health-promoting processes.…”

Section: Introductionmentioning

confidence: 99%

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Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway

Luo

Shen

et al. 2023

Front. Nutr.

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Natural polysaccharides (NPs) possess numerous health-promoting effects, such as liver protection, kidney protection, lung protection, neuroprotection, cardioprotection, gastrointestinal protection, anti-oxidation, anti-diabetic, and anti-aging. Nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway is an important endogenous antioxidant pathway, which plays crucial roles in maintaining human health as its protection against oxidative stress. Accumulating evidence suggested that Nrf2 antioxidant pathway might be one of key regulatory targets for the health-promoting effects of NPs. However, the information concerning regulation of NPs on Nrf2 antioxidant pathway is scattered, and NPs show different regulatory behaviors in their different health-promoting processes. Therefore, in this article, structural features of NPs having regulation on Nrf2 antioxidant pathway are overviewed. Moreover, regulatory effects of NPs on this pathway for health-promoting effects are summarized. Furthermore, structure-activity relationship of NPs for health-promoting effects by regulating the pathway is preliminarily discussed. Otherwise, the prospects on future work for regulation of NPs on this pathway are proposed. This review is beneficial to well-understanding of underlying mechanisms for health-promoting effects of NPs from the view angle of Nrf2 antioxidant pathway, and provides a theoretical basis for the development and utilization of NPs in promoting human health.

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Section: Regulation Of Nps On Nrf2 Antioxidant Pathway For Health-pro...mentioning

confidence: 99%

Section: Regulation Of Nps On Nrf2 Antioxidant Pathway For Health-pro...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway

Luo

Shen

et al. 2023

Front. Nutr.

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“…Clinically, a number of studies have displayed that Salvia miltiorrhiza can improve kidney function in CKD patients by increasing the glomerular filtration rate (GFR) and creatinine clearance (Ccr) and reducing serum creatinine (SCr) and proteinuria, but this conclusion is yet to be verified [ 5 ]. Research studies also reveal that Salvia miltiorrhiza could alleviate kidney injury via inhibiting oxidative stress and apoptosis [ 6 ] and exerting prominent renal protective effects in iron-overloaded mice by decreasing of iron deposition and suppression of lipid peroxidation and apoptosis in the kidney [ 7 ]. Tanshinone IIA significantly attenuates kidney fibrosis by inhibiting the recruitment of fibrocytes into the kidney [ 8 ] and decreases renal damage in diabetic rats via inhibiting oxidative stress and inflammation [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Salvia miltiorrhiza for Treating Chronic Kidney Diseases: A Systematic Review and Meta-Analysis

Zhang

Li²,

Yang³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. This meta-analysis evaluated the effects and potential harms of Salvia miltiorrhiza or its extracts Salvianolate and Tanshinone for the treatment of population with a chronic kidney disease (CKD). Methods. We searched for the randomized clinical trials (RCTs) through databases including the Cochrane Library, PubMed, Embase, Web of Science, Current Controlled Trials, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform (Wanfang Data), China Biology Medicine Disc (SinoMed), and Chinese Clinical Trial Registry (ChiCTR). Meta-analysis was performed with STATA 16 software after data extraction. The risk of bias was assessed with the Cochrane risk-of-bias tool (RoB 2.0), and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework was employed to evaluate the quality of evidence. Result. A total of 32 studies were included involving 2264 participants. Compared to the control group, the treatment group significantly decreased serum creatinine (SCr) (SMD −0.60, 95% CI −0.79 to −0.41, P < 0.0001 ), blood urea nitrogen (BUN) (SMD −0.66, 95% CI −0.81 to −0.50, P < 0.0001 ), Cystatin C (CysC) (SMD −5.16, 95% CI −14.84 to 4.53, P = 0.297 ), 24 hour urine protein (24 h UPE) (SMD −0.70, 95% CI −1.21 to −0.19, P = 0.008 ), time to initiation of dialysis (Log RR 0.43, 95% CI 0.23 to 0.81, P = 0.0089 ), serum total cholesterol (TC) (SMD −0.53, 95% CI −0.88 to −0.17, P = 0.0042 , P = 0.0035 ), plasma fibrinogen (FIB) (SMD −0.79, 95% CI −1.12 to −0.46, P < 0.0001 ), C-reactive protein (CRP) (SMD −0.56, 95% CI −0.93 to −0.19, P = 0.0029 ); increased creatinine clearance (Ccr) (SMD 0.92, 95% CI 0.43 to 1.41, P = 0.0002 ), glomerular filtration rate (GFR) (SMD 0.56, 95% CI 0.30 to 0.83, P < 0.001 ), effective rate (Log RR 0.30, 95% CI 0.23 to 0.37, P < 0.0001 ), and hemoglobin (Hb) (SMD 0.42, 95% CI 0.13 to 0.71, P = 0.0042 ). Moreover, the incidences of adverse effects were similar between the two groups. Conclusions. Salvia miltiorrhiza or its extracts Salvianolate and Tanshinone, as a complementary therapy to conventional medicine, presents potential impacts to improve kidney functions and delay the progression of CKD without obvious adverse effects. However, the certainty of the evidence and the risk of bias are suboptimal and further clinical studies are still required to determine the underlying effects.

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“…As important metabolic sites and excretory pathways of antibiotics such as FFC, kidneys of broilers are very vulnerable to its toxic and side effects. Once the kidneys of broilers are damaged by excessive FFC, their development will be seriously hindered ( Wang et al, 2022 ). Previous studies found that FFC caused oxidative stress response in kidneys of chicks by inhibiting the expression of related factors in Nrf2-ARE pathway, and increased the apoptotic rate of renal histocytes by upregulating the expression of pro-apoptotic factors ( Wang et al, 2021b ; Lu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Florfenicol induced renal inflammatory response and apoptosis via cell adhesion molecules signaling pathway

Wang

Liu²,

Liu³

et al. 2022

Poultry Science

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Salvia miltiorrhiza polysaccharides alleviates florfenicol induced kidney injury in chicks via inhibiting oxidative stress and apoptosis

Cited by 11 publications

References 40 publications

Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway

Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway

Efficacy and Safety of Salvia miltiorrhiza for Treating Chronic Kidney Diseases: A Systematic Review and Meta-Analysis

Florfenicol induced renal inflammatory response and apoptosis via cell adhesion molecules signaling pathway

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