Salvage Therapy Options for Local Prostate Cancer Recurrence After Primary Radiotherapy: a Literature Review

Golbari, Nicole M.; Katz, Aaron E.

doi:10.1007/s11934-017-0709-4

Cited by 54 publications

(52 citation statements)

References 118 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…48,49 However, no data are available for combined ADT and RT in the re-EBRT setting. 10,45,50 In our series, concomitant ADT was prescribed in 16 (25%) patients, this percentage being lower than in other series. 20,46 Whenever possible, exclusive local therapy was proposed, reserving ADT for future tumor progression.…”

Section: Discussioncontrasting

confidence: 70%

Reirradiation for isolated local recurrence of prostate cancer: Mono-institutional series of 64 patients treated with salvage stereotactic body radiotherapy (SBRT)

Jereczek‐Fossa

Rojas

Zerini

et al. 2019

BJR

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 70%

Reirradiation for isolated local recurrence of prostate cancer: Mono-institutional series of 64 patients treated with salvage stereotactic body radiotherapy (SBRT)

Jereczek‐Fossa

Rojas

Zerini

et al. 2019

BJR

View full text Add to dashboard Cite

“…Crouzet et al reported that for locally recurrent prostate carcinoma after field external beam radiation therapy, salvage HIFU should be initiated early because of high rates of cancer‐specific and metastasis‐free survival rates. Golbari and Katz concluded that there did not appear to be any significant difference in overall survival for more‐invasive salvage radical prostatectomy compared to minimally invasive treatment of recurrent carcinoma. A consensus on a trial design to study focal salvage therapy has been published, but to date, no authoritative recommendations can be made regarding the treatment of focal recurrent disease because of the absence of randomized data and protocols .…”

Section: High‐intensity Focused Us In the Treatment Of Recurrencementioning

confidence: 99%

Histotripsy: The Next Generation of High‐Intensity Focused Ultrasound for Focal Prostate Cancer Therapy

Dubinsky

Khokhlova

et al. 2019

J of Ultrasound Medicine

View full text Add to dashboard Cite

This article reviews the most current methods and technological aspects of highintensity focused ultrasound (HIFU), which is termed histotripsy. The rationale for focal therapy for prostate carcinoma rather than prostatectomy, which is being used extensively throughout Europe and Asia, is presented, and an argument for why HIFU is the modality of choice for primary therapy and recurrent disease is offered. The article presents a review of the technical advances including higher ultrasound beam energy than current thermal HIFU which allows for more accurate tissue targeting, less collateral tissue damage, and faster treatment times. Finally, the article presents a discussion about the advantage of ultrasound guidance for histotripsy in preference to magnetic resonance imaging guidance primarily based on cost, ease of application, and portability.

show abstract

“…Several treatment options for localized prostate cancer are available including the two standard treatment options, radical prostatectomy, and radiation therapy. Although the treatment outcomes have improved the procedure and devices, the biochemical recurrence rate had not decreased yet [1] [2] [3]. Recently, many alternative and less invasive treatments have been developed for localized prostate cancer [4] [5].…”

Section: Introductionmentioning

confidence: 99%

Salvage Transrectal High-Intensity Focused Ultrasound Therapy for Patients with Recurrence of Vesico-Urethral Anastomosis after Radical Prostatectomy

Hayashi¹,

Hayashi²,

Oka³

et al. 2019

OJU

View full text Add to dashboard Cite

Background: Salvage radiotherapy has been used as the treatment for patients with local recurrence after radical prostatectomy. However, the therapy is time-consuming and it experiences adverse effects of some kind. Simple and less invasive treatment is highly anticipated. Objectives: To evaluate the outcomes of salvage transrectal high-intensity focused ultrasound (HIFU) therapy for patients with localized recurrence of a vesicourethral anastomosis (VUA) after radical prostatectomy. Material and methods: Sixteen patients with suspected local recurrence of a VUA after prostatectomy were treated with HIFU. All patients had prostate-specific antigen (PSA) failure (>0.2 ng/ml), positive findings of a VUA with biopsy and/or MRI, TRUS and CT, and no distant metastasis by CT, MRI and bone scintigraphy before HIFU. Recurrence after HIFU was determined by PSA failure (>0.2 ng/ml), histological findings, metastasis and start of systemic therapies. Results: HIFU treatments were performed in 16 patients, and followed-up for 7-159 months (median 46.5). The pre-HIFU PSA levels ranged from 0.318 to 3.1 ng/ml. Sonication time ranged from 9-42 min. All patients had a decline of PSA after HIFU, and 88% of the PSA nadir was <0.2 ng/ml. Recurrence free survival (RFS) rates of 5 year were 31.3%. Nadir PSA was significantly associated with recurrence, whereas initial PSA, pre-HIFU PSA, duration and risk group after prostatectomy were not. There were no intraoperative adverse effects. In the 1-3 months after HIFU, there was some difficulty voiding in 4 cases (grade 1), urgency incontinence in 3 cases (grade 1 or 2). Conclusion: HIFU therapy for local recurrence after prostatectomy may become a feasible salvage therapeutic option because of its ease and simple procedure.

show abstract

Salvage Therapy Options for Local Prostate Cancer Recurrence After Primary Radiotherapy: a Literature Review

Cited by 54 publications

References 118 publications

Reirradiation for isolated local recurrence of prostate cancer: Mono-institutional series of 64 patients treated with salvage stereotactic body radiotherapy (SBRT)

Reirradiation for isolated local recurrence of prostate cancer: Mono-institutional series of 64 patients treated with salvage stereotactic body radiotherapy (SBRT)

Histotripsy: The Next Generation of High‐Intensity Focused Ultrasound for Focal Prostate Cancer Therapy

Salvage Transrectal High-Intensity Focused Ultrasound Therapy for Patients with Recurrence of Vesico-Urethral Anastomosis after Radical Prostatectomy

Contact Info

Product

Resources

About