Salvage therapy expands highly cytotoxic and metabolically fit resilient CD8
+
T cells via ME1 up-regulation
Joanina K. Gicobi,
Zhiming Mao,
Grace DeFranco
et al.
Abstract:Patients with advanced cancers who either do not experience initial response to or progress while on immune checkpoint inhibitors (ICIs) receive salvage radiotherapy to reduce tumor burden and tumor-related symptoms. Occasionally, some patients experience substantial global tumor regression with a rebound of cytotoxic CD8
+
T cells. We have termed the rebound of cytotoxic CD8
+
T cells in response to salvage therapy as T cell resilience and examined the underlyin… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.