Salvage Surgery by Composite Resection for Epidermoid Carcinoma of the Tonsillar Region

Pacheco-Ojeda, Luis; Marandas, P.; Juliéron, M.; Lusinchi, A.; Mamelle, G.; Luboinski, B.

doi:10.1001/archotol.1992.01880020079019

Cited by 24 publications

(12 citation statements)

References 13 publications

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“…In our series, the postoperative mortality was 2.0%, whereas 37.0% of the patients had postoperative complications. These numbers are similar to those of other published series 10, 23. Salvage surgeries had complications and postoperative mortality rates not significantly different from the complications that occur in the primary treatment of advanced tumors 24, 25…”

Section: Discussionsupporting

confidence: 89%

Temporal and spatial expression profile of the novelarmadillo-related gene,Alex2, during testicular differentiation in the mouse embryo

2005

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In a screen for transcripts differentially expressed during gonadal development in mouse embryos, we identified the novel armadillo-related gene, Alex2. The armadillo (arm) family of proteins share a 42 amino acid tandem repeat motif called the arm domain, through which they interact with different binding partners. These intracellular proteins are implicated in a variety of developmental processes, including cell proliferation, migration, maintenance of tissue integrity, and tumorigenesis. Alex2 is a member of a novel subgroup within the arm family, encoding a protein with a single arm domain and a putative transmembrane or signal sequence. Alex2 has a developmentally regulated expression profile during embryogenesis in the mouse. In the urogenital system, it is strongly expressed in the developing testis but is down-regulated during ovarian development. Alex2 expression is localized within the interstitial cell lineage of the developing testis, which gives rise to peritubular myoid, endothelial, and fetal Leydig cells. Alex2 is also expressed in the developing forebrain and somites and in dorsal root ganglia. In testicular cell lines, Alex2 fusion proteins localize to membrane structures within the cell. The expression profile of Alex2 suggests that it plays a role in the development of several tissues during embryogenesis, notably testicular differentiation. In the developing testis, its expression profile suggests that Alex2 has a role in specification or development of the interstitial cell lineage. Developmental Dynamics 233:188 -193, 2005.

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Section: Discussionsupporting

confidence: 89%

Temporal and spatial expression profile of the novelarmadillo-related gene,Alex2, during testicular differentiation in the mouse embryo

2005

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“…The survival rates in our cohort are in agreement with those reported by other groups. 14,21,25,31,32 The technical challenges, the poor outcome, and the concerns about quality of life drove some authors to the conclusion that salvage surgery should not be attempted in patients with advanced OPSCC after initial treatment failure. 21,33,34 Salvage surgery after full-course chemoradiation is usually reported to be associated with a high risk of complications.…”

Section: Discussionmentioning

confidence: 99%

Salvage treatment for recurrent oropharyngeal squamous cell carcinoma

2009

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“…Spiro et al, 5 in their study of 1,069 subjects in which cervical dissection was performed for the treatment of oral and oropharyngeal carcinoma, reported that the 5 year survival rate in patients with ipsilateral nodal metastasis was 28% but significantly decreased to 8% in cases of bilateral metastasis. In addition, the rate of cure in the cases of nodal recurrence is only approximately 30%, which further emphasizes the importance of cervical lymph node treatment in primary therapy 6,7 …”

Section: Discussionmentioning

confidence: 99%

Management of Contralateral N0 Neck in Tonsillar Squamous Cell Carcinoma

et al. 2005

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The risk of contralateral occult neck involvement in above T3 staged tonsillar squamous cell carcinomas with unilateral metastases was high (approximately 21%), and patients who present with a contralateral metastatic neck have a worse prognosis than those who are staged as N0. Therefore, we advocate an elective contralateral neck treatment in tonsillar squamous cell carcinoma patients with ipsilateral node metastases.

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Salvage Surgery by Composite Resection for Epidermoid Carcinoma of the Tonsillar Region

Cited by 24 publications

References 13 publications

Temporal and spatial expression profile of the novelarmadillo-related gene,Alex2, during testicular differentiation in the mouse embryo

Temporal and spatial expression profile of the novelarmadillo-related gene,Alex2, during testicular differentiation in the mouse embryo

Salvage treatment for recurrent oropharyngeal squamous cell carcinoma

Management of Contralateral N0 Neck in Tonsillar Squamous Cell Carcinoma

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