Salvage surgery after failure of very accelerated radiotherapy in advanced head-and-neck squamous cell carcinoma

Temam, Stéphane; Pape, Erwin; Janot, F.; Wibault, P.; Juliéron, M.; Lusinchi, A.; Mamelle, G.; Marandas, P.; Luboinski, B.; Bourhis, Jean

doi:10.1016/j.ijrobp.2004.12.062

Cited by 77 publications

(58 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surgical salvage is possible in only approximately 20% of patients (12,13). Reirradiation using brachytherapy, 3D conformal radiotherapy, or IMRT combined with chemotherapy are used with some success, but are associated with treatment-related morbidity (14)(15)(16).…”

Section: Discussionmentioning

confidence: 99%

Stereotactic Body Radiation Therapy for Primary, Recurrent, and Metastatic Tumors in the Head-and-Neck Region

Siddiqui

Patel

Khan

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

127

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Stereotactic Body Radiation Therapy for Primary, Recurrent, and Metastatic Tumors in the Head-and-Neck Region

Siddiqui

Patel

Khan

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

127

View full text Add to dashboard Cite

“…After radical treatment of head and neck cancer, about 20-50% of patients are diagnosed with the locoregional recurrence during first two years [1][2][3]. The main treatment for recurrent disease is salvage surgery, but in most cases, surgery is not feasible due to the high risk of complications and morbidity, and only 15-30% of patients are suitable for surgical salvage [4][5][6][7][8], and 5-year overall survival is 16-36% [9][10][11][12][13][14]. When chemotherapy is administered for recurrence, the response rate is up to 35-40%, and median overall survival is about 10% [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Re-irradiation for Recurrent Head and Neck Cancer

Rudžianskas¹,

Kupčinskaitė-Noreikienė²

2017

Radiotherapy

View full text Add to dashboard Cite

After radical treatment of head and neck cancer about 20-50% of patients are diagnosed with the locoregional recurrence during first two years. The main treatment for recurrent disease is salvage surgery, but in most cases, surgery is not feasible due to the high risk of complications and morbidity, and only 20% of patients are suitable for surgical salvage. Reirradiation is an effective treatment method with acceptable toxicity, but this treatment method is limited to normal tissue tolerance to a total dose. When chemotherapy is administered for recurrence, the response rate is up to 40%, so with the advancement of technical measures, after introduction of intensity-modulated radiotherapy, fractionated stereotactic body radiation therapy, high-dose-rate brachytherapy, proton beam reirradiation, a reirradiation is increasingly more often used for head and neck cancer relapse treatment. In this chapter, we will discuss about reirradiation with curative intent using new different radiation techniques (intensity-modulated radiotherapy (IMRT), stereotactic body radiation therapy (SBRT), high-dose-rate brachytherapy (HDR-BRT) and proton beam reirradiation (PBRT) for previously irradiated head and neck cancer and present recommendations for retreatment of head and neck cancer relapse using reirradiation alone or with systemic chemotherapy/biologic therapy.

show abstract

“…Surgical resection offers the best chance of control. However, this is feasible in only 20% of cases [7,8]. Standard fractionated external beam radiation therapy (EBRT) can be delivered with acceptable side effects, but in many cases, the dose delivered is inadequate to control the recurrence.…”

Section: Introductionmentioning

confidence: 99%

Stereotactic body radiation therapy in head and neck, gynecologic, and pediatric malignancies

2012

View full text Add to dashboard Cite

Stereotactic body radiotherapy (SBRT) is increasingly being used in the clinic. While most data from this new technology has been in the treatment of early stage lung cancer and sites of oligometastasis in the lung, liver or bone, limited experience exists in other disease sites. Recently, more and more physicians are using SBRT for retreatment. In the head and neck, multiple articles have now been published reporting outcomes in patients with recurrence or those with new primary lesions in previously irradiated areas. The response rates to SBRT have been good; however, long-term control and toxicity are still a major problem. In gynecological malignancies, the literature on SBRT is more limited with initial experience treating para-aortic nodal metastasis from cervical and uterine cancer with excellent local control. Current studies are underway utilizing SBRT with the inclusion of chemotherapy in the treatment regimen of metastatic gynecologic cancers. In pediatrics, where problems of late toxicity are a concern, there is scant information. With all these advances, long-term follow-up is needed to look at complication rates with this form of treatment. In this review, we will discuss the rationale and possible applications of SBRT in head and neck, gynecological, and pediatric tumors. We will outline the advantages and disadvantages including possible complications of SBRT. We will also present some illustrative cases on how we have used this technology in our practice.

show abstract

Salvage surgery after failure of very accelerated radiotherapy in advanced head-and-neck squamous cell carcinoma

Cited by 77 publications

References 19 publications

Stereotactic Body Radiation Therapy for Primary, Recurrent, and Metastatic Tumors in the Head-and-Neck Region

Stereotactic Body Radiation Therapy for Primary, Recurrent, and Metastatic Tumors in the Head-and-Neck Region

Re-irradiation for Recurrent Head and Neck Cancer

Stereotactic body radiation therapy in head and neck, gynecologic, and pediatric malignancies

Contact Info

Product

Resources

About