Salvage Stereotactic Body Radiotherapy for Isolated Lymph Node Recurrent Prostate Cancer: Single Institution Series of 94 Consecutive Patients and 124 Lymph Nodes

Jereczek‐Fossa, Barbara Alicja; Fanetti, Giuseppe; Fodor, C.; Ciardo, D.; Santoro, Luigi; Francia, C.; Muto, Matteo; Surgo, A.; Zerini, Dario; Marvaso, Giulia; Timon, G.; Romanelli, P.; Rondi, E.; Comi, S.; Cattani, Federica; Golino, Federica; Mazza, Stefano; Matei, Deliu Victor; Ferro, Matteo; Musi, Gennaro; Nolè, Franco; Cobelli, Ottavio De; Ost, Piet; Orecchia, Roberto

doi:10.1016/j.clgc.2017.01.004

Cited by 72 publications

(102 citation statements)

References 37 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The exclusion reasons with references are listed in Data S2. Finally, 14 articles were selected for data extraction and subsequent qualitative synthesis.…”

Section: Resultsmentioning

confidence: 99%

“…Choline PET/CT was the most commonly used evaluation method and was present in all the studies . However, six of them allowed its substitution for less accurate tests (18F‐FDG PET/CT, MRI, CT and/or Bone Scan) in a minority of patients (<5%).…”

Section: Resultsmentioning

confidence: 99%

“…Toxicity was assessed according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer (RTOG/EORTC) criteria in six (43%) studies and the Common Terminology Criteria for Adverse Events (CTCAE) in five (35%) others . Three (21%) articles did not describe the criteria adopted …”

Section: Resultsmentioning

confidence: 99%

“…Risk of bias assessment is reported in Table . Seven studies, containing 52% of patients, scored 7 or more ‘yes’ answers and were considered to be low risk of bias …”

Section: Resultsmentioning

confidence: 99%

“…The summary of the outcomes of individual studies is presented in Table . A 2‐year PFS rate was reported by seven articles, which are shown in Figure . Local control rates varied from 82 to 100% among researches with low risk of bias.…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Use of stereotactic body radiation therapy for oligometastatic recurrent prostate cancer: A systematic review

et al. 2018

View full text Add to dashboard Cite

The purpose of this study is to evaluate the effectiveness and safety of stereotactic body radiation therapy (SBRT) in the management of oligometastatic recurrent prostate cancer (PCa) by means of a systematic review. Six databases were searched (CENTRAL, Embase, LILACS, PubMed, Scopus and Web of Science). Additionally, hand-searching and grey literature search were performed. The main outcomes were progression-free survival (PFS) and toxicity rates. Androgen deprivation therapy-free survival (ADT-FS), local control, pattern of recurrence, cancer-specific survival and overall survival were also assessed. Risk of bias and quality of evidence were judged with the aid of specific tools. Fourteen studies were included, involving 661 patients and 899 lesions (561 nodal, 336 bone, 2 liver). Median PFS and ADT-FS were around 1 to 3 years. Local control rates varied from 82 to 100% among researches with low risk of bias. Acute and late grade 2 toxicity was observed in 2.4% and 1.1% of the patients, respectively. One case of acute and two cases of late grade 3 toxicity were registered. Only one randomized study addresses this topic. Although it does not meet all the eligibility criteria, it is useful for the discussion. A quantitative analysis was not possible, nor were subgroup analyses, due to the significant heterogeneity of the interventions and outcomes reported. Longer follow-up period is required. SBRT seems to be a safe approach to metastatic lesions that might provide disease control and defer androgen deprivation therapy (ADT). Local control is better when higher radiation doses are employed.

show abstract

“…The exclusion reasons with references are listed in Data S2. Finally, 14 articles were selected for data extraction and subsequent qualitative synthesis.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Risk of bias assessment is reported in Table . Seven studies, containing 52% of patients, scored 7 or more ‘yes’ answers and were considered to be low risk of bias …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations