Salvage Re-Irradiation for Recurrent Head and Neck Cancer

Lee, Nancy; Chan, Kelvin K.; Bekelman, Justin E.; Zhung, J.; Mechalakos, James; Narayana, Ashwatha; Wolden, Suzanne L.; Venkatraman, Ennapadam; Pfister, David G.; Kraus, Dennis H.; Shah, Jatin P.; Zeléfsky, Michael J.

doi:10.1016/j.ijrobp.2006.12.055

Cited by 249 publications

(263 citation statements)

References 37 publications

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“…These results are comparable with those in other studies 23, 24. Within this subgroup, patients with a recurrence undergoing a total laryngectomy experienced even better outcomes with a 5‐year locoregional control rate of 59%.…”

Section: Discussionsupporting

confidence: 87%

“…It should be noted that this group of patients was relatively small (14 patients), no concurrent chemotherapy was administered, and patient selection may have played a strong role in the outcome. Others reported poor outcome for these patients as well, with 2‐year locoregional control rates of 14% and 19% with part of the patients receiving concurrent chemotherapy 19, 23. We emphasize that, if possible, surgery should be the treatment of choice for this category of patients.…”

Section: Discussionmentioning

confidence: 78%

“…A borderline higher locoregional control was observed in patients treated with IMRT in univariate analysis, although this effect disappeared in multivariate analysis. A retrospective reirradiation series with 105 patients, however, did show an increased locoregional progression‐free survival in multivariate analysis for patients reirradiated with IMRT 23. A high‐precision radiotherapy technique, such as IMRT or VMAT should be used to optimize normal tissue‐sparing.…”

Section: Discussionmentioning

confidence: 99%

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Reirradiation of head and neck cancer: Long‐term disease control and toxicity

et al. 2017

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BackgroundThe purpose of this study was to report long‐term disease control and late radiation toxicity for patients reirradiated for head and neck cancer.MethodsWe conducted a retrospective analysis of 137 patients reirradiated with a prescribed dose ≥45 Gy between 1986 and 2013 for a recurrent or second primary malignancy. Endpoints were locoregional control, overall survival (OS), and grade ≥4 late complications according to European Organization for Research and Treatment of Cancer (EORTC)/Radiation Therapy Oncology Group (RTOG) criteria.ResultsFive‐year locoregional control rates were 46% for patients reirradiated postoperatively versus 20% for patients who underwent reirradiation as the primary treatment (p < .05). Sixteen cases of serious (grade ≥4) late toxicity were seen in 11 patients (actuarial 28% at 5 years). In patients reirradiated with intensity‐modulated radiotherapy (IMRT), a borderline improved locoregional control was observed (49% vs 36%; p = .07), whereas late complication rates did not differ.ConclusionReirradiation should be considered for patients with a recurrent or second primary head and neck cancer, especially postoperatively, if indicated. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1122–1130, 2017

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

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Reirradiation of head and neck cancer: Long‐term disease control and toxicity

et al. 2017

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“…This review highlights the possible potential of BNCT in the management of patients with LRHNC, but BNCT should be compared against other emerging local re-irradiation therapeutic options for patients with LRHNC -Stereotactic Radiosurgery (Roh et al, 2009), IMRT (Lee et al, 2007) or Proton Therapy (Stuschke et al, 2013). While the availability of BNCT facilities remains limited, it has been estimated that accelerator-based BNCT facilities can be installed in hospitals at a similar cost to that of presently used for standard radiotherapy (Blue and Yanch, 2003).…”

Section: Resultsmentioning

confidence: 99%

Clinical potential of boron neutron capture therapy for locally recurrent inoperable previously irradiated head and neck cancer

Lim

Quah

Leech

et al. 2015

Applied Radiation and Isotopes

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“…RT-related morbidity ranges from xerostomia, dysphagia, speech impairment, and dental dysfunction to severe subcutaneous fibrosis and carotid rupture [13,14]. Adverse effects of conventionally utilized chemotherapy include ototoxicity, nephrotoxicity, neurotoxicity, cardiac toxicity, and loss of reproductive capability [15 -18, 13].…”

Section: Discussionmentioning

confidence: 99%

Role of Surgery in the Treatment of Oropharyngeal Squamous Cell Carcinoma: A Population-Based Review

Jamal¹,

Jalisi²

2017

CSROA

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Background: Since most oropharyngeal carcinomas are locally advanced at presentation, patients are often treated with radiation therapy and/or chemotherapy. However, for early stage oropharyngeal carcinoma, national guidelines state that it can be treated by either primary surgery or radiotherapy. This study analyse national survival rates of oropharyngeal squamous cell carcinoma for surgical and nonsurgical treatment modalities.

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Salvage Re-Irradiation for Recurrent Head and Neck Cancer

Cited by 249 publications

References 37 publications

Reirradiation of head and neck cancer: Long‐term disease control and toxicity

Reirradiation of head and neck cancer: Long‐term disease control and toxicity

Clinical potential of boron neutron capture therapy for locally recurrent inoperable previously irradiated head and neck cancer

Role of Surgery in the Treatment of Oropharyngeal Squamous Cell Carcinoma: A Population-Based Review

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