Salvage Radiotherapy for Patients with PSA Relapse Following Radical Prostatectomy: Issues and Challenges

Detection of a second malignancy in prostate cancer patients by using [18F]Choline PET/CT: a case series

“…In the setting of PSA relapse after local therapy different treatment strategies can be chosen either salvage EBRT alone or in combination with anti-androgen therapy or anti-androgen therapy alone [18]. The latter option is applied in a palliative intent and should be considered in patients with bad performance status, patients with high PSA values (>2 ng/mL) with a high risk of metastatic disease or in patients where salvage radiotherapy cannot be carried due to other reasons (e.g., previous pelvic EBRT) [19].…”

Anti-3-[ 18 F]FACBC Positron Emission Tomography-Computerized Tomography and 111 In-Capromab Pendetide Single Photon Emission Computerized Tomography-Computerized Tomography for Recurrent Prostate Carcinoma: Results of a Prospective Clinical Trial

“…Conventional methodology, including CT, MR, transrectal ultrasound and bone scan, have the disadvantage of less than optimal diagnostic performance. 4–7 Thus, molecular techniques have been used, including imaging based on an antibody to prostate specific membrane antigen using 111 In-capromab pendetide (ProstaScint). 7,8 …”

EUS-guided fiducial placement after radical prostatectomy before targeted radiation therapy for prostate cancer recurrence

“…However, salvage radiotherapy is the only treatment that offers a potential cure in these patients, whereas undetectable PSA levels have been reported in 55% to 57% of patients. 4,5 Because of the potential morbidity associated with radiation treatment, it is critical to precisely define target margins and correct for total positioning errors, particularly in the setting of radical prostatectomy. Before the introduction of fiducials, prostate bed localization and alignment was facilitated by intraoperative placement of markers, surgical clips, cone-beam CT measurements of soft tissue shifts, or by immobilization devices such as inflating rectal balloons before each radiation session.…”