Salvage operations for patients with persistent or recurrent cancer of the maxillary sinus after superselective intra-arterial infusion of cisplatin with concurrent radiotherapy

Abstract

The purpose of our study was to evaluate the feasibility of salvage surgery for patients with persistent or recurrent maxillary sinus cancer after superselective intra-arterial cisplatin infusion with concomitant radiotherapy (RADPLAT). We retrospectively analyzed 61 patients with maxillary sinus cancer who underwent RADPLAT.Chemotherapy comprised 100-120 mg/m 2 superselective intra-arterial cisplatin administered at a median rate of four times weekly. Concurrent radiation therapy was administered at a median dose of 65Gy. Persistent/recurrent maxillary sinus cancer was observed in 17 patients. Salvage surgery was performed in 11 patients.Persistent/recurrent primary disease was controlled in 8 of 11 patients undergoing salvage surgery (72.7%). Seven of 11 patients undergoing salvage surgery (63.6%) have survived without any evidence of disease. The 5-year overall survival rate of patients undergoing salvage surgery was calculated to be 60.6%. The incidence rate of significant perioperative complications was 18.2% (2/11). Salvage surgery for patients with persistent/recurrent maxillary sinus cancer after RADPLAT is considered to be both safe and successful. We also consider that salvage surgery is good option when persistent/recurrent maxillary sinus cancer is observed after RADPLAT.

Outcome of Definitive and Postoperative Radiotherapy in Patients with Sinonasal Squamous Cell Carcinomas

“…The salvage treatment protocol at our institution may have contributed to the improvement in survival. Although there is limited literature regarding salvage treatment for patients with progression or recurrence (22), 5 of the 25 patients who had locoregional recurrence achieved locoregional control with salvage treatment in our study.…”

Successful salvage treatment of refractory recurrence of maxillary sinus carcinoma using image-guided high-dose-rate interstitial brachytherapy

“…A large number of clinical studies have confirmed that salvage surgery or repeated radiotherapy could be chosen as the local treatment of relapse in these patients [ 4 , 5 ]. However, functional and cosmetic outcomes after surgical treatment for patients with advanced recurrent tumors are far from satisfactory [ 11 ]. The complication rate of salvage surgery after intensive chemoradiotherapy for patients with head and neck cancer has been reported to be 11-63% [ 12 ].…”

“…Sakashita et al . [ 11 ] reported that 18% of patients with recurrent cancer of the maxillary sinus developed serious operative complications after salvage surgery. An observational study by Iwata et al .…”

Utility of a Hybrid IVIM-DKI Model to Predict the Development of Distant Metastasis in Head and Neck Squamous Cell Carcinoma Patients

“…Advances in treatment methods such as a combination of surgery, chemotherapy and radiotherapy have led to improved local control of primary lesions such as sinonasal cavity or pharynx squamous cell carcinomas (SCCs). 1 – 3 However, patients may develop distant metastasis after treatment, even if the primary lesion was successfully controlled. 4 In addition, systematic screening by whole-body scanning using CT or 18 F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/CT at short intervals can be used to detect distant metastases in HNSCC patients after the curative treatment, but this may not be cost-effective.…”