Salvage Operation in Case of Oligometastatic Disease

Abstract

In general, prognosis of stage IV non-small cell lung cancer is poor, and treatment is mostly palliative. However, oligometastatic disease is currently recognized as a specific entity with a better prognosis. We report a patient where combined chemoradiotherapy and salvage surgery led to extraordinary long-term survival.

Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

“…Lastly, salvage surgery may be considered in case of residual or progressive disease in the primary tumour or metastatic site when no other treatment options remain or specific complications occur, such as formation of a lung abscess in a necrotic cavity [300]. Long-term survival may be obtained in selected patients with limited distant involvement, but only case reports have been published so far [V, C] [301].…”

Salvage surgery after high-dose radiotherapy

“…Recently, we reported a case of salvage lung surgery in a patient with oligometastatic disease who initially presented with a femoral bone metastasis from NSCLC treated by osteosynthesis and local radiotherapy (38). Chemoradiation was administered to the primary lung cancer located in the right upper lobe.…”

Oligometastatic non-small cell lung cancer: is there a role for locoregional therapy?

“…Long-term survival after treatment of oligometastatic disease may be observed. We recently reported a 50-year-old patient who presented with a painful femoral bone metastasis which was found to be a single distant metastasis from a right upper lobe lung cancer (12). The bone metastasis was treated by osteosynthesis for stabilization followed by local radiotherapy.…”