Salvage of recurrent head and neck squamous cell carcinoma after primary curative surgery

Wong, Lai‐San; Wei, William I.; Lam, Lai Kun; Yuen, Andrea

doi:10.1002/hed.10310

Cited by 201 publications

(158 citation statements)

References 31 publications

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“…Salvage surgery leads to durable disease control in 15% to 30% of the patients (1)(2)(3). When cancer is considered unresectable, the disease is almost uniformly fatal with a median survival time of only a few months (3,4).…”

Section: Introductionmentioning

confidence: 99%

Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-and-Neck Cancer: Final Analysis of a Phase I/II Trial

Kankaanranta

Seppälä

Koivunoro

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

213

182

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Section: Introductionmentioning

confidence: 99%

Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-and-Neck Cancer: Final Analysis of a Phase I/II Trial

Kankaanranta

Seppälä

Koivunoro

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

213

182

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“…The surgical salvage rate was higher in primary laryngeal and oral cavity tumors, possibly because of the easier and, therefore, earlier clinical detection of recurrences in these areas, and the increased feasibility of further resection and reconstruction [11]. Recurrent laryngeal carcinoma has been successfully treated for a long time, especially when total laryngectomy has not been previously performed, since most recurrent tumors are confined to the laryngeal compartments.…”

mentioning

confidence: 99%

“…In addition, recurrent neck disease significantly increased the probability of a second recurrence after salvage surgery [8], and the prognosis is even more dismal after previous neck dissection [11]. Recurrent cervical tumor in the field of a previous modified radical or radical neck dissection is often unresectable.…”

mentioning

confidence: 99%

When is reoperative surgery not indicated for recurrent head and neck squamous cell carcinoma?

Rodrigo

Kowalski

Silver

et al. 2013

Eur Arch Otorhinolaryngol

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“…For Wong et al [23], surgical salvage is only feasible for early recurrent tumor. In this series, published by Goodwin et al [24], median disease free survival was 17.9 months in 109 patients, and this correlated strongly with recurrent stage, weakly with recurrent site, and not at all with time to presalvage recurrence.…”

Section: Discussionmentioning

confidence: 99%

Salvage surgery after failure of non surgical therapy for advanced head and neck cancer

Dequanter¹,

Vercruysse²,

Shahla³

et al. 2011

OJST

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Introduction: for organ and function preservation, chemoradiotherapy is gaining popularity for primary treatment of advanced head and neck cancer, reserveing surgery for salvage. Methods: Retrospective outcome analysis to determine the results of salvage surgery after failure of primary treatment of advanced head and neck cancer by chemoradiotherapy. 104 patients with advanced head and cancer were initially treated by chemoradiotherapy. Follow-up was evaluated in 27 patients undergoing salvage surgery for recurrent tumor (larynx n = 13; oral cavity n = 9; hypopharynx n = 5). The initial tumor is stage T3 in 11 cases and T4 in 16 cases. 10 patients had primary tumors stage III and 17 patients had tumors stage IV. Results: One postoperative death occured following surgery. The overall incidence of complications was 9/ 27 (%). Recurrent disease developed at the primary initially treated in 25 cases and in the neck in 2 cases after a mean follow-up of 11 months (3 -136 months). After salvage surgery, loco-regional recurrence and/ or distant disease developed in 10/27 patients after a mean follow-up of 4 months. 6/10 (60%) patients died after re-recurrence despite salvage chemotherapy. Conclusion: Salvage surgery after failure of initial chemoradiotherapy is burdened with high morbidity and bad oncological outcome. We demonstrated that it is difficult to salvage locally recurrent head and neck cancer especially at more advanced T-stages or when tumor recur. The limited effect of surgical salvage for recurrent tumor need to be addressed when choosing the initial treatment plan.

show abstract

Salvage of recurrent head and neck squamous cell carcinoma after primary curative surgery

Abstract: There was a moderate chance of cure after surgical salvage of locoregional recurrent HNSCC. Surgical salvage was, however, only feasible for early recurrent tumor. Close follow-up surveillance of early recurrence is essential after primary treatment of patients.

Cited by 201 publications

References 31 publications

Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-and-Neck Cancer: Final Analysis of a Phase I/II Trial

Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-and-Neck Cancer: Final Analysis of a Phase I/II Trial

When is reoperative surgery not indicated for recurrent head and neck squamous cell carcinoma?

Salvage surgery after failure of non surgical therapy for advanced head and neck cancer

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