Salvage High-Intensity Focused Ultrasound (Hifu) Therapy for Locally Recurrent Prostate Cancer After Primary Hifu or External Beam Radiotherapy (Ebrt)

Seo, S.I.; Jeon, Sung-eok; Jo, Moon Ki; Lee, H.M.; Choi, H.Y.

doi:10.1016/s1569-9056(08)60192-x

Cited by 3 publications

(3 citation statements)

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“…Seo et al [9] found that the PSA nadir level > 0.5 ng/ml was the only significant predictor on multivariate analysis associated with failure of salvage HIFU therapy. However, there is not yet a definition of successful salvage HIFU treatment based on PSA nadir.…”

Section: Discussionmentioning

confidence: 99%

A prospective study of salvage high-intensity focused ultrasound for locally radiorecurrent prostate cancer: Early results

Berge

Baco

Karlsen

2010

Scandinavian Journal of Urology and Nephrology

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Section: Discussionmentioning

confidence: 99%

A prospective study of salvage high-intensity focused ultrasound for locally radiorecurrent prostate cancer: Early results

Berge

Baco

Karlsen

2010

Scandinavian Journal of Urology and Nephrology

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“…The pre-HIFU biopsy Gleason score and the positive biopsy percentage did not influence the progression free survival rate. Seo et al, 41 in their series of 30 patients, found that the PSA nadir level was the only significant predictor on multivariate analysis.…”

Section: Prognostic Factorsmentioning

confidence: 96%

“…[57][58][59][60][61][62][63][64][65][66] In modern cryotherapy series, the reported rates of complications were rectal fistula in 0-1%, incontinence in 13-17% and perineal pain in 4-5.6%. 67,68 The age and performance status of the salvage prostatectomy and 39 32 Not reported 3 months 50% PSA nadir p0.2 ng ml Murat et al 40 72 80% 39 months 44% (5 years) Nadir+2 Seo et al 41 30 NA 12 months 56.7% Definition NA Mallik et al 42 68 NA 6 months 54.4% PSA X0.5…”

Section: Complications/toxicity Of Salvage Hifumentioning

confidence: 99%

Salvage HIFU for recurrent prostate cancer after radiotherapy

Chalasani

Martínez

Lim

et al. 2008

Prostate Cancer Prostatic Dis

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Recurrent disease following primary radiotherapy for localized prostate cancer is a common problem, occurring in up to 46% of patients. For these patients, therapeutic options include salvage prostatectomy, salvage cryotherapy, salvage high-intensity focused ultrasound (HIFU), hormonal therapy or observation. This review will focus on the emerging evidence for salvage HIFU. There are no randomized or prospective studies in this area. Efficacy results of 17-57% have been reported from retrospective case series, with reported toxicity including rectal fistula in 0-16%, and incontinence in 10-50%. The ideal patient, while yet to be clearly defined, should have preradiotherapy low or intermediate risk disease. Salvage HIFU appears most appropriate for those patients with histologically proven local recurrence only, with a life expectancy of at least 5 years and with some medical comorbidities rendering them not ideal for salvage prostatectomy.

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High-intensity focused ultrasound: where are we and where to from here?

Williams¹,

Martinez²,

Chalasani³

et al. 2010

Expert Review of Anticancer Therapy

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High-intensity focused ultrasound (HIFU) has evolved significantly from early work treating cerebral lesions. The ability to treat deep soft-tissue lesions without damaging superficial structures led to it being used for prostate cancer treatment both in the primary and salvage setting. Primary HIFU treatment for prostate cancer leads to 5-year disease free survival rates of up to 70-80% in selected patients with little morbidity; however, comparative studies with established treatment modalities are lacking. Salvage treatment with HIFU leads to significantly more morbidity than primary treatment yet the morbidity appears the same or less than other salvage treatments following external-beam radiation treatment. We believe that with the development of more advanced imaging techniques combined with multimodality prostate imaging that HIFU's future lies in focal treatment of prostate cancer.

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Salvage High-Intensity Focused Ultrasound (Hifu) Therapy for Locally Recurrent Prostate Cancer After Primary Hifu or External Beam Radiotherapy (Ebrt)

Cited by 3 publications

References 0 publications

A prospective study of salvage high-intensity focused ultrasound for locally radiorecurrent prostate cancer: Early results

A prospective study of salvage high-intensity focused ultrasound for locally radiorecurrent prostate cancer: Early results

Salvage HIFU for recurrent prostate cancer after radiotherapy

High-intensity focused ultrasound: where are we and where to from here?

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