Salvage high-dose-rate interventional radiotherapy (brachytherapy) for locally relapsed prostate cancer after radical prostatectomy and subsequent external irradiation

Soror, Tamer; Melchert, Corinna; Rades, Dirk; Merseburger, Axel S.; Kovács, György

doi:10.5114/jcb.2023.128845

Cited by 2 publications

(2 citation statements)

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“…Среднее время наблюдения составило 34 мес. Биохимический рецидив был выявлен у 4 пациентов, у 4 пациентов отмечался продолженный рост опухоли, у 1 -отдаленные метастазы [25].…”

Section: рис 4 планирующая система Oncentra Prostate Nucletron распре...unclassified

Salvage high-dose rate brachytherapy for local recurrence of prostate cancer after radical prostatectomy

Solodkiy,

Pavlov,

Dzidzaria

et al. 2024

Onkourologiâ

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Background. The current need for optimization of salvage treatment methods is dictated by the growing expansion of indications for radical prostatectomy in many centers in the developed countries of the world.Aim. To evaluate the effectiveness, toxicity, and technical characteristics of high-dose rate brachytherapy in treatment of local prostate cancer (PCa) recurrences after radical prostatectomy.Materials and methods. Between January 2015 and December 2020, salvage high-dose rate brachytherapy was performed in 17 patients at the Russian Scientific Center of Roentgenology and Radiology for local recurrence of PCa after radical prostatectomy. All patients underwent multiparametric magnetic resonance imaging of the pelvis at the stage of primary diagnosis in order to determine macroscopic tissue component in the prostate bed area. To rule out regional and distant metastases, all patients underwent positron emission tomography with 18F- or 68Ga-labeled prostate-specific membrane antigen. All patients included in the study underwent perineal biopsy of the prostate bed and seminal vesicles.Results. Median follow-up in the treatment group was 35.7 (24–54) months. Overall survival was 100 %. Prostatespecific antigen-specific survival was 88.2 %. There were no local recurrences of PCa in the treatment group. In patients with local PCa recurrence, significant predictors of treatment failure were the presence of clinically extremely high risk of progression at initial diagnosis (p = 0.003), development of biochemical relapse up to 24 months after main treatment (p = 0.001), and increased blood level of prostate-specific antigen above 10 ng/mL during registration of biochemical relapse (p = 0.002).Conclusion. High-dose rate brachytherapy is a safe and effective salvage treatment for local recurrence of PCa after radical prostatectomy. In addition to the brachytherapy technique, the diagnostic stage is also of great importance providing visualization of the exact location of tumor recurrence.

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Section: рис 4 планирующая система Oncentra Prostate Nucletron распре...unclassified

Salvage high-dose rate brachytherapy for local recurrence of prostate cancer after radical prostatectomy

Solodkiy,

Pavlov,

Dzidzaria

et al. 2024

Onkourologiâ

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“…The implementation of this approach leads to a steep dose gradient, ensuring the protection of vital organs at risk (OAR). Consequently, HDR-IRT emerges as a viable and effective salvage modality for managing-recurrent cancers in different anatomical locations [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers

Soror,

Paul,

Melchert

et al. 2023

Cancers

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(1) Background: to report on the use of high-dose-rate (HDR) interventional radiotherapy (brachytherapy, IRT) as a salvage treatment for patients with regionally relapsed head and neck cancers. (2) Methods: A retrospective study of 60 patients treated with HDR-IRT for loco-regionally relapsed head and neck cancers at our institution (2016–2020). Treatment procedure, results, and related toxicities were collected. Local and overall survival outcomes were analyzed. (3) Results: The median follow-up was 22.4 months. Twenty-nine (48.3%) patients had locoregional recurrences with a median time of 28.9 months. The local-recurrence free-survival was 88.1% and 37.3% at 3 years and 5 years. At the last follow-up, 21 patients were alive and the median time to death was 24 months. The overall survival was 39.2% and 16.6% at 3 years and 5 years. Collectively, there were 28 events of grade ≥ 3 late toxicities recorded in 21 patients (35%). (4) Conclusions: Salvage HDR-IRT combined with surgery offers a second-line curative treatment option for regionally relapsed head and neck cancers with acceptable outcomes and toxicities.

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Salvage high-dose-rate interventional radiotherapy (brachytherapy) for locally relapsed prostate cancer after radical prostatectomy and subsequent external irradiation

Cited by 2 publications

References 40 publications

Salvage high-dose rate brachytherapy for local recurrence of prostate cancer after radical prostatectomy

Salvage high-dose rate brachytherapy for local recurrence of prostate cancer after radical prostatectomy

Salvage High-Dose-Rate Interventional Radiotherapy (Brachytherapy) Combined with Surgery for Regionally Relapsed Head and Neck Cancers

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