Salvage abdominal irradiation for refractory non-Hodgkin′s lymphoma

Akoum, Riad; Brihi, Emile; Saade, Michel; Hanna, Therese; Chahine, Georges

doi:10.4103/0973-1482.37406

Cited by 3 publications

(1 citation statement)

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“…Although controversial, radiation in the abdominal area may be less toxic. Radiation can also be applied in refractory cases ( 28 , 29 ). Many studies confirm the viability and effectiveness of salvage radiation of tumor mass in the abdominal area ( 30 - 34 ).…”

Section: Radiation In the Abdominal Regionmentioning

confidence: 99%

Infradiaphragmal Radiotherapy in Patients with Lymphoma: Volume Definition and Side Effects

Galunić-Bilić

Šantek

2018

ACC

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SUMMARY – Lymphomas are very radiosensitive and radiotherapy (RT) was the first treatment modality that enabled cure. It is the most effective single modality for local control of lymphomas. However, as a local form of treatment, curative intention is only possible if all lymphoma tissue can be incorporated in the volume to be irradiated with the prescribed total irradiation dose. That is why RT is a single modality only in early stage of nodular lymphocyte predominance Hodgkin’s lymphoma and low grade non-Hodgkin’s lymphoma. In most patients, RT can be used as consolidation therapy after chemotherapy or as salvage after failure of chemotherapy. In the past two decades, irradiation techniques have been improved in order to spare critical tissues and reduce toxicity. Although effective, RT is a neglected modality of treatment because of the appearance of new drugs and fear of side effects after irradiation. Radiation has been shown to be effective in the treatment of all stages and forms of lymphoma. Study data are still mostly derived from patients that received supradiaphragmal RT; therefore, there is no agreement about the best management approach in patients with infradiaphragmal lymphoma.

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Section: Radiation In the Abdominal Regionmentioning

confidence: 99%

Infradiaphragmal Radiotherapy in Patients with Lymphoma: Volume Definition and Side Effects

Galunić-Bilić

Šantek

2018

ACC

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Efficacy and toxicity of infradiaphragmal radiotherapy fields in lymphoma patients: a single-centre experience

et al. 2023

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Clinical Tolerance in Large Field Radiotherapy - The Knowledge Gained Over the Last Ten Years

Gocheva¹

2010

Folia Medica

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Malignant disorders are still far from being successfully managed in spite of the apparent progress achieved by surgical treatment, high energy radiotherapy (RT) and chemotherapy (CHT). They keep being the second most frequent cause of lethal outcomes both in Bulgaria and in most countries of the world. One of the promising approaches to increasing the efficaciousness of treatment is development and use of methods that are in full accord with the modern requirements of a complex therapy. Over the last fifty years, large field radiation techniques, applied as systemic therapy in oncology, have been investigated and established. These techniques show the transition in oncology to using actively various variants of large field radiotherapy (LFR), the "heavy artillery" of oncoradiologic practice, as an alternative or adjunct therapy to chemotherapy (CHT). In the present paper we review the current knowledge in the field and present the clinical experience accumulated over the last ten years with respect to clinical tolerance in the major large-field radiotherapy techniques--total body irradiation, half body irradiation, whole abdominal irradiation, total and partial lymphoid irradiation. Described in detail are the contemporary knowledge about clinical and hematologic tolerance in total body irradiation as part of the myelo- and nonmyeloablative conditioning regimens as well as in half body irradiation as a systemic therapy in oncology. We also present the amassed experience in clinical tolerance in partial body irradiation in the form of whole abdominal and total or partial lymphoid irradiation. Another point worth noting based again on the experience gained over the last ten years is that for LFR we need to develop a radiotherapy technique that is designed carefully to achieve an optimal therapeutic effect that should include the disease control, good clinical tolerance and reduction of post-radiotherapy sequelae.

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Salvage abdominal irradiation for refractory non-Hodgkin′s lymphoma

Abstract: Salvage radiotherapy for refractory abdominal NHL is a feasible alternative for both follicular and diffuse subtypes and may provide significant palliation and prolongation of survival. It is less effective in patients with primary refractory NHL than in those with refractory relapsed NHL.

Cited by 3 publications

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Infradiaphragmal Radiotherapy in Patients with Lymphoma: Volume Definition and Side Effects

Infradiaphragmal Radiotherapy in Patients with Lymphoma: Volume Definition and Side Effects

Efficacy and toxicity of infradiaphragmal radiotherapy fields in lymphoma patients: a single-centre experience

Clinical Tolerance in Large Field Radiotherapy - The Knowledge Gained Over the Last Ten Years

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