Salting-out assisted liquid-liquid extraction method combined with GC-MS for the determination of topiramate in aqueous solutions: development and application of the methodology

Almeida, Janiele Mayara Ferreira de; Silva, Elânia Maria Fernandes; Veríssimo, Lourena Mafra; Fernandes, Nedja Suely

doi:10.1080/01496395.2019.1624570

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…As a result, the introduction of salt-assisted liquid-liquid extraction (SALLE), an efficient extraction method for polar to moderately polar organic compounds, was made feasible by using more polar and water-miscible organic extraction solvents like acetonitrile, isopropanol, acetone, ethanol, and methanol, among others. In the SALLE method, organic solvent is separated from the mixture, and a two-phase system is created as a result of addition of inorganic salt [ 39 ]. When using inorganic or organic salts, the salting out effect increases the ionic strength of the solution and decreases the solubility of the weak electrolyte in water, which causes the target analyte to be extracted into the organic solvent, resulting in high extraction efficiency of polar or slightly polar target analyte in an aqueous sample [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the SALLE method, organic solvent is separated from the mixture, and a two-phase system is created as a result of addition of inorganic salt [ 39 ]. When using inorganic or organic salts, the salting out effect increases the ionic strength of the solution and decreases the solubility of the weak electrolyte in water, which causes the target analyte to be extracted into the organic solvent, resulting in high extraction efficiency of polar or slightly polar target analyte in an aqueous sample [ 39 ]. The SALLE method produces extracts with solutes in organic solvent that may be evaporated and reconstituted with an appropriate solvent for preconcentration and analysis by HPLC or GC [ 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

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A Highly Selective Analytical Method Based on Salt-Assisted Liquid-Liquid Extraction for Trace-Level Enrichment of Multiclass Pesticide Residues in Cow Milk for Quantitative Liquid Chromatographic Analysis

Bekele,

Yohannes,

Megersa

2023

International Journal of Analytical Chemistry

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In this study, a simple, inexpensive, selective, and fast salting-out assisted liquid-liquid extraction (SALLE) technique coupled with high-pressure liquid chromatography-diode array detection (HPLC-DAD) was developed for the extraction, preconcentration, and analysis of trace level seven multiclass pesticide residues in pasteurized and raw cow milk samples. The significant factors that affect the extent to which the target analytes are extracted, such as the type of extraction solvent and its volume, the type and concentration of salting-out salts, the pH of the solution, and the extraction time, have been investigated. Under optimum conditions, the correlation coefficient (r2) was obtained within a range of 0.9982–0.9997 for a broad linear range concentration of 2–1500 ng·mL−1. Reliable sensitivity was achieved with limits of detection (LODs) and limits of quantification (LOQs) ranging from 0.58–2.56 ng·mL−1 and 1.95–8.51 ng·mL−1, respectively. While precision with interday and intraday in terms of relative standard deviations (RSDs) was observed in the range of 1.97 ̶ 7.88% and 4.52 ̶ 8.04%, respectively. The results of the precision studies reveal that good repeatability and reproducibility (RSDs <9) were achieved, thus showing a low variability extraction of the developed method. Finally, the proposed and validated approach was effectively used to extract and determine pesticide residues in real milk matrices; however, the target analytes were not detected in all samples.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Highly Selective Analytical Method Based on Salt-Assisted Liquid-Liquid Extraction for Trace-Level Enrichment of Multiclass Pesticide Residues in Cow Milk for Quantitative Liquid Chromatographic Analysis

Bekele,

Yohannes,

Megersa

2023

International Journal of Analytical Chemistry

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“…The liquid chromatography tandem mass spectrometry (LC-MS) and ultra-performance liquid chromatography (UPLC) methods have also been documented for TPM analysis in its bulk form and dosage forms [ 17 , 18 ]. Other approaches for determining TPM in its formulations have also been published, including flow-injection spectrometry, nuclear magnetic resonance (NMR) spectrometry, and gas-chromatography mass-spectrometry (GC-MS) tests [ 19 , 20 , 21 ]. TPM in plasma and serum samples has also been determined using HPLC-based techniques [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

A Greener Stability-Indicating High-Performance Thin-Layer Chromatography Approach for the Estimation of Topiramate

et al. 2022

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Despite various reported analytical methods for topiramate (TPM) analysis, greener analytical approaches are scarce in literature. As a consequence, the objective of the current research is to design a normal-phase stability-indicating high-performance thin-layer chromatography (SI-HPTLC) methodology for TPM analysis in marketed tablet dosage forms that is rapid, sensitive, and greener. TPM was derivatized densitometrically and analyzed at 423 nm in visible mode with anisaldehyde-sulfuric acid as the derivatizing agent. The greener SI-HPTLC technique was linear in the 30–1200 ng band−1 range. In addition, the suggested SI-HPTLC methodology for TPM analysis was simple, rapid, cheaper, precise, robust, sensitive, and environmentally friendly. The greener SI-HPTLC method was able to detect TPM along with its degradation products under acid, base, and oxidative degradation conditions. However, no TPM degradation was recorded under thermal and photolytic stress conditions. TPM contents in commercial tablet dosage forms were recorded as 99.14%. Using 12 different principles of green analytical chemistry, the overall analytical GREEnness (AGREE) score for the greener SI-HPTLC method was calculated to be 0.76, confirming the proposed normal-phase SI-HPTLC method’s good greener nature. Overall, these results demonstrated that the suggested SI-HPTLC technique for TPM measurement in pharmaceutical products was reliable and selective.

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A density-tunable liquid-phase microextraction system based on deep eutectic solvents for the determination of polycyclic aromatic hydrocarbons in tea, medicinal herbs and liquid foods

et al. 2021

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Salting-out assisted liquid-liquid extraction method combined with GC-MS for the determination of topiramate in aqueous solutions: development and application of the methodology

Cited by 4 publications

References 28 publications

A Highly Selective Analytical Method Based on Salt-Assisted Liquid-Liquid Extraction for Trace-Level Enrichment of Multiclass Pesticide Residues in Cow Milk for Quantitative Liquid Chromatographic Analysis

A Highly Selective Analytical Method Based on Salt-Assisted Liquid-Liquid Extraction for Trace-Level Enrichment of Multiclass Pesticide Residues in Cow Milk for Quantitative Liquid Chromatographic Analysis

A Greener Stability-Indicating High-Performance Thin-Layer Chromatography Approach for the Estimation of Topiramate

A density-tunable liquid-phase microextraction system based on deep eutectic solvents for the determination of polycyclic aromatic hydrocarbons in tea, medicinal herbs and liquid foods

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