Salt sensitive purely zwitterionic physical hydrogel for prevention of postoperative tissue adhesion

Fang, Yuelin; Huang, Susu; Gong, Xin; King, Julia A.; Wang, Yanqing; Zhang, Jicheng; Yang, Xiaoye; Wang, Qiong; Zhang, Yabin; Zhai, Guangxi; Ye, Lei

doi:10.1016/j.actbio.2022.12.045

Cited by 28 publications

(20 citation statements)

References 41 publications

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“…100 μL of the FITC-labeled Gel@M/CuO 2 /DOX 36 was also implanted into the cavities of mice after surgery to observe in vivo degradation. At predetermined time intervals (0, 3, 5, 7, 9, 11, and 13 days), the mice were imaged by a small animal imaging system (IVIS Spectrum, PerkinElmer).…”

Section: Materials Cell Lines and Animals 3-[2-(methacryloyloxy)mentioning

confidence: 99%

“…32−35 Zwitterionic poly-(sulfobetaine methacrylate) (PSBMA) can be easily synthesized and self-assembled into a hydrogel in saline. 36,37 As a physical hydrogel formed by electrostatic interactions, the PSBMA hydrogel is biodegradable under physiological conditions, thereby releasing therapeutic agents without the need for surgical extraction. Therefore, the PSBMA hydrogel is a suitable carrier for local and sustained drug release.…”

Section: Introductionmentioning

confidence: 99%

“…Luo et al reported a ROS-responsive hydrogel for sustained codelivery of photosensitizers and ICB antibodies. The local delivery systems based on injectable hydrogels have been recently developed for preventing postoperative tumor recurrence. − Among implant materials, zwitterionic hydrogels with antiprotein adsorption properties could effectively reduce the possibility of exogenous immune reactions and have been extensively studied in the biomedical field. − Zwitterionic poly(sulfobetaine methacrylate) (PSBMA) can be easily synthesized and self-assembled into a hydrogel in saline. , As a physical hydrogel formed by electrostatic interactions, the PSBMA hydrogel is biodegradable under physiological conditions, thereby releasing therapeutic agents without the need for surgical extraction. Therefore, the PSBMA hydrogel is a suitable carrier for local and sustained drug release.…”

Section: Introductionmentioning

confidence: 99%

“…First, we synthesized the PSBMA polymer using free radical polymerization. Driven by electrostatic interactions, PSBMA self-assembles into a hydrogel in saline with antiprotein adsorption properties . Tumor-targeted nanoparticles (M/CuO 2 /DOX) and STING agonist 2′,3′-cGAMP were coloaded into the hydrogel to form the final formulation (Gel@M/CuO 2 /DOX/STING) (Scheme a,b).…”

Section: Introductionmentioning

confidence: 99%

“…Driven by electrostatic interactions, PSBMA self-assembles into a hydrogel in saline with antiprotein adsorption properties. 36 Tumor-targeted nanoparticles (M/CuO 2 /DOX) and STING agonist 2′,3′-cGAMP were coloaded into the hydrogel to form the final formulation (Gel@M/CuO 2 /DOX/STING) (Scheme 1a,b). Body fluid in the TME could affect the ion interaction of the hydrogel skeleton, making the hydrogel degrade, followed by releasing small size nanoparticles (M/CuO 2 /DOX) and 2′,3′-cGAMP.…”

Section: Introductionmentioning

confidence: 99%

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Injectable Zwitterionic Physical Hydrogel with Enhanced Chemodynamic Therapy and Tumor Microenvironment Remodeling Properties for Synergistic Anticancer Therapy

Fang,

Huang,

et al. 2023

ACS Nano

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Surgical resection is the first-line therapy for breast cancer. However, residual tumor cells and the highly immunosuppressive tumor microenvironment (TME) continue to have a serious impact on tumor recurrence and metastasis postresection. Implantation of an in situ hydrogel system postresection has shown to be an effective treatment with great clinical potential. Herein, an injectable zwitterionic hydrogel system was developed for local drug delivery with enhanced immune activation and prevention of tumor recurrence. Driven by electrostatic interactions, poly-(sulfobetaine methacrylate) (PSBMA) self-assembles into a hydrogel in saline, achieving low protein adsorption and tunable biodegradability. The chemotherapy drug doxorubicin (DOX) was loaded into copper peroxide nanoparticles (CuO 2 /DOX), which were coated with macrophage membranes to form tumor-targeting nanoparticles (M/CuO 2 /DOX). Next, M/CuO 2 /DOX and the stimulator of interferon genes (STING) agonist 2′,3′-cGAMP were coloaded into PSBMA hydrogel (Gel@M/CuO 2 /DOX/STING). The hydrophilic STING agonist was first released by diffusion from hydrogel to activate the STING pathway and upregulate interferon (IFN) signaling related genes, remodeling the immunosuppressive TME. Then, M/CuO 2 /DOX targeted the residual tumor cells, combining with DOX-induced DNA damage, immunogenic tumor cell death, and copper death. Hence, this work combines chemodynamic therapy with STING pathway activation in TME, encouraging residual tumor cell death, promoting the maturation of dendritic cells, enhancing tumor-specific CD8 + T cell infiltration, and preventing postoperative recurrence and metastasis.

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Section: Materials Cell Lines and Animals 3-[2-(methacryloyloxy)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Injectable Zwitterionic Physical Hydrogel with Enhanced Chemodynamic Therapy and Tumor Microenvironment Remodeling Properties for Synergistic Anticancer Therapy

Fang,

Huang,

et al. 2023

ACS Nano

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Injectable pH‐Responsive CI1040 Delayed‐Release Hydrogel for the Treatment of Tendon Adhesion

Wu,

Pang,

et al. 2024

Adv Funct Materials

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Tendon injuries, often leading to debilitating adhesions, pose significant challenges in clinical practice. Conventional treatments have limitations, necessitating novel strategies. Injectable hydrogels, known for their biocompatibility, have shown promise. To enhance their antiadhesive properties, researchers have started incorporating drugs. Existing drug delivery systems often peak in the initial days, falling short during the fibroblast proliferation phase which occurs ≈1 week after injury. In this research, CI1040 is selected as an antiadhesion drug, encapsulated within zeolitic imidazolate framework‐8(ZIF‐8), and incorporated into oxidized hyaluronic acid/N‐carboxyethyl chitosan(OHA/CEC) hydrogel(Gel), resulting in the synthesis of CI1040@ZIF@Gel. This unique pH‐responsive drug release system involves encapsulating CI1040 within ZIF‐8, a substance that degrades under acidic conditions while remaining stable in physiological environments. This system selectively releases the drug during the fibroblast proliferation phase, responding to the localized pH reduction post‐tendon injury. CI1040@ZIF@Gel exerted a 65% inhibition on extracellular signal‐regulated kinase (ERK) phosphorylation, reducing the production of collagen types III (Col III) in the adhesion area by 56%. These results indicate that CI1040@ZIF@Gel can effectively inhibit fibroblast proliferation and adhesion through the interleukin 9 receptor/mitogen‐activated protein kinase/extracellular signal‐regulated kinase(IL9r/MEK/ERK) pathway, while also acting as a physical barrier to prevent the formation of tendon adhesion.

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Injectable Asymmetric Adhesive‐Antifouling Bifunctional Hydrogel for Peritoneal Adhesion Prevention

Zhao,

Sun,

et al. 2023

Adv Healthcare Materials

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Peritoneal adhesion is a common problem after abdominal surgery and can lead to various medical problems. In response to the lack of in situ retention and pro‐wound healing properties of existing anti‐adhesion barriers, this work reports an injectable adhesive‐antifouling bifunctional hydrogel (AAB‐hydrogel). This AAB‐hydrogel can be constructed by “two‐step” injection. The tissue adhesive hydrogel based on gallic acid‐modified chitosan and aldehyde‐modified dextran is prepared as the bottom hydrogel (B‐hydrogel) by Schiff base reaction. The aldehyde‐modified zwitterionic dextran/carboxymethyl chitosan‐based hydrogel is formed on the B‐hydrogel surface as the antifouling top hydrogel (T‐hydrogel). The AAB‐hydrogel exhibits good bilayer binding and asymmetric properties, including tissue adhesive, antifouling, and antimicrobial properties. To evaluate the anti‐adhesion effect in vivo, the prepared hydrogels are injected onto the wound surface of a mouse abdominal wall abrasion‐cecum defect model. Results suggest that the AAB‐hydrogel has antioxidant capacity and can reduce the postoperative inflammatory response by modulating the macrophage phenotype. Moreover, the AAB‐hydrogel could effectively inhibit the formation of postoperative adhesions by reducing protein deposition, and resisting fibroblast adhesions and bacteria attacking. Therefore, AAB‐hydrogel is a promising candidate for the prevention of postoperative peritoneal adhesions.

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Salt sensitive purely zwitterionic physical hydrogel for prevention of postoperative tissue adhesion

Cited by 28 publications

References 41 publications

Injectable Zwitterionic Physical Hydrogel with Enhanced Chemodynamic Therapy and Tumor Microenvironment Remodeling Properties for Synergistic Anticancer Therapy

Injectable Zwitterionic Physical Hydrogel with Enhanced Chemodynamic Therapy and Tumor Microenvironment Remodeling Properties for Synergistic Anticancer Therapy

Injectable pH‐Responsive CI1040 Delayed‐Release Hydrogel for the Treatment of Tendon Adhesion

Injectable Asymmetric Adhesive‐Antifouling Bifunctional Hydrogel for Peritoneal Adhesion Prevention

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