Salt and Pepper for Point-of-Care Diagnostics

Furin, Dominik; Sämann, Marc; Proll, Günther; Schubert, M.B.; Gauglitz, Güenter

doi:10.1016/j.proeng.2011.12.020

Cited by 2 publications

(1 citation statement)

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“…It should be noted, that compared to other label-free sensors developed for the simultaneous determination of the two-analytes, the sensor developed exceeded in performance either with respect to detection sensitivity or the duration of the assay. There are only two publications regarding the simultaneous determination of CRP and D-dimer with label-free biosensors: the first employing a surface acoustic wave sensor (SAW) complemented with a fluidic that allows detection in sequence of the targeted markers [ 46 ], and the second targeting to a Point-of-Care system based on reflectometric interference spectroscopy (RIfS) [ 47 ]. Compared to the first system, the WLRS sensor has approximately 5-and 40-times lower quantification limits for CRP and D-dimer, respectively; however, the assay time of the proposed sensor is approximately 3-times longer.…”

Section: System Development and Applicationsmentioning

confidence: 99%

Development and Bioanalytical Applications of a White Light Reflectance Spectroscopy Label-Free Sensing Platform

et al. 2017

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The development of a sensing platform based on white light reflectance spectroscopy (WLRS) is presented. The evolution of the system, from polymer film characterization and sensing of volatile organic compounds to biosensor for the label-free determination of either high (e.g., proteins) or low molecular weight analytes (e.g., pesticides), is described. At the same time, the passage from single to multi-analyte determinations, and from a laboratory prototype set-up to a compact device appropriate for on-site determination, is outlined. The improvements made on both the sensor and the optical set-up, and the concomitant advances in the analytical characteristics and the robustness of the assays performed with the different layouts, are also presented. Finally, the future perspectives of the system, aiming for the creation of a standalone instrument to be used by non-experts, will be discussed.

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Section: System Development and Applicationsmentioning

confidence: 99%