Salt: a matter of balance

Persson, Pontus B.

doi:10.1111/apha.12651

Cited by 1 publication

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with the overfill theory, plasma renin activity and aldosterone concentration were negatively correlated with overhydration in this analysis . In the presence of renal salt sensitivity, it is once more important to advise the patient to limit salt intake to prevent sodium retention and exacerbation of blood pressure control …”

Section: Proteasuria Confers Salt Sensitivity In Nephrotic Syndromesupporting

confidence: 82%

Proteasuria—The impact of active urinary proteases on sodium retention in nephrotic syndrome

Artunc¹,

Wörn²,

Schork³

et al. 2019

Acta Physiologica

View full text Add to dashboard Cite

Sodium retention and extracellular volume expansion are typical features of patients with nephrotic syndrome. In recent years, from in vitro data, endoluminal activation of the epithelial sodium channel (ENaC) by aberrantly filtered serine proteases has been proposed as an underlying mechanism. Recently, this concept was supported in vivo in nephrotic mice that were protected from proteolytic ENaC activation and sodium retention by the use of aprotinin for the pharmacological inhibition of urinary serine protease activity. These and other findings from studies in both rodents and humans highlight the impact of active proteases in the urine, or proteasuria, on ENaC-mediated sodium retention and edema formation in nephrotic syndrome. Targeting proteasuria could become a therapeutic approach to treat patients with nephrotic syndrome. However, pathophysiologically relevant proteases remain to be identified. In this review, we introduce the concept of proteasuria to explain tubular sodium avidity and conclude that proteasuria can be considered as a key mechanism of sodium retention in patients with nephrotic syndrome. K E Y W O R D Saprotinin, ENaC, nephrotic syndrome, proteasuria, proteinuria, proteolysis, serine protease

show abstract

Section: Proteasuria Confers Salt Sensitivity In Nephrotic Syndromesupporting

confidence: 82%