Salsolinol and dopamine in rat medial basal hypothalamus after chronic ethanol exposure

A Critical Evaluation of Influence of Ethanol and Diet on Salsolinol Enantiomers in Humans and Rats

“…Effects of ethanol on DA levels have been shown to vary depending on many parameters such as dose or duration of ethanol treatment or the brain regions examined (Dar and Wooles, 1984; Murphy et al, 1983; Myers et al, 1985a; Sjöquist et al, 1982). A decreasing trend of DA levels in both NAC and STR observed in our study is in agreement with previous findings.…”

Locomotor stimulant effects of acute and repeated intrategmental injections of salsolinol in rats: role of μ-opioid receptors

“…In the 1970s and 1980s and even in the early 1990s, Sal was postulated to be an important factor contributing to the biochemical basis of alcoholism (Cohen and Collins 1970;Davis and Walsh 1970;Duncan and Deitrich 1980;Melchior and Myers 1977). The interest in this compound subsequently declined mainly because of the contradictory results reported in relation to the increase of Sal levels in the brain after alcohol consumption (Baum et al 1999;Matsubara et al 1987;Myers et al 1985;Sjoquist et al 1982). In terms of its endogenous identification, it is true that measurements of Sal levels were analytically challenging because of the very low levels of Sal in the brain tissue (Starkey et al 2006) which was also another conflictive aspect.…”

Mystic Acetaldehyde: The Never-Ending Story on Alcoholism

“…In fact, beginning from the first evidences of salsolinol formation in the brain of rodents after ethanol administration brought in the mid 70 by Collins and Bigdeli (1975), different laboratories have obtained controversial data. Actually, some of these reports show an increase of salsolinol levels (Myers et al, 1985; Matsubara et al, 1987; Jamal et al, 2003a,b,c; Starkey et al, 2006; Rojkovicova et al, 2008) while others show no alterations in the brain after different protocols of ethanol administration (O’Neill and Rahwan, 1977; Baum et al, 1999; Haber et al, 1999; Lee et al, 2010). Moreover, the investigations reporting increased brain salsolinol upon chronic ethanol intake or chronic ethanol administration, were performed in rats allowed to access ad libitum lab chow either before and throughout the study (Sjöquist et al, 1982).…”