Salphen metal complexes as tunable G-quadruplex binders and optical probes

Karim, Nurul Huda Abd; Mendoza, Óscar; Shivalingam, Arun; Thompson, Alexander; Ghosh, Sushobhan; Kuimova, Marina K.; Vilar, Ramón

doi:10.1039/c3ra44793f

Cited by 79 publications

(83 citation statements)

References 32 publications

(66 reference statements)

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“…The interaction with the G‐quadruplex grooves and loops is also taken into account for improving the selectivity for G‐quadruplex versus duplex DNA. Among the compounds able to target G‐quadruplexes, a number of metal complexes bearing aromatic ligands have been reported, including those of porphyrin, salphens, and salophens . In this context, we have designed a new extended planar ligand, based on a pyrazine core, namely dipyrazino[2,3‐ a :2′,3′‐ h ]phenazine (dph; Figure a).…”

Section: Introductionmentioning

confidence: 99%

New Ruthenium‐Based Probes for Selective G‐Quadruplex Targeting

Piraux

Bar

Abraham

et al. 2017

Chemistry A European J

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Telomeric regions containing G-quadruplex (G4) structures play a pivotal role in the development of cancers. The development of specific binders for G4s is thus of great interest in order to gain a deeper understanding of the role of these structures, and to ultimately develop new anticancer drug candidates. For several years, Ru complexes have been studied as efficient probes for DNA. Interest in these complexes stems mainly from the tunability of their structures and properties, and the possibility of using light excitation as a tool to probe their environment or to selectively trigger their reaction with a biological target. Herein, we report on the synthesis and thorough study of new Ru complexes based on a novel dipyrazino[2,3-a:2',3'-h]phenazine ligand (dph), obtained through a Chichibabin-like reaction. Luminescence experiments, surface plasmon resonance (SPR), and computational studies have demonstrated that these complexes behave as selective probes for G-quadruplex structures.

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Section: Introductionmentioning

confidence: 99%

New Ruthenium‐Based Probes for Selective G‐Quadruplex Targeting

Piraux

Bar

Abraham

et al. 2017

Chemistry A European J

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“…The luminescence of these compounds was generated from excited states formed by metal‐to‐ligand charge transfer and ligand‐centered transitions. Vilar et al carried out fluorescence microscopy imaging of two emissive Pt(salen)s in four different cell lines . They found that the two compounds localized at different organelles.…”

Section: Metallosalens For Fluorescence Molecular Imagingmentioning

confidence: 99%

Section: Metallosalens For Fluorescence Molecular Imagingmentioning

confidence: 99%

Introducing Metallosalens into Biological Studies: The Renaissance of Traditional Coordination Complexes

2017

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Metal complexes attract great attention in the context of biological applications because of their attractive structures and intriguing physicochemical properties. Combinations of the core structures of salen ligands and various metal ions provide many possibilities for incorporation of diverse biological functionalities unachievable with conventional small-molecule organic compounds. The past decade has witnessed remarkable progress in the field of metallosalens; here we present

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“…In fact, even if DNA occurs mainly as duplex structure, recent research efforts have been dedicated to the design of metal compounds able to target DNA non-canonical structures. These compounds include, for instance, bulky ruthenium(II) complexes able to bind bulged DNAs [18], iron(II) supramolecular helicate binding to DNA three-way junctions [19], and a series of metal containing polycyclic planar aromatic compounds, like metal-salphen [20] and platinum(II) terpyridine [21] complexes, that bind to G-quadruplex DNAs [22]. It is clear that all of these non-canonical structures represent a valid target for structure-and shape-selective binding agents [3].…”

Section: Introductionmentioning

confidence: 99%

Covalent and non-covalent binding of metal complexes to RNA

Alberti

Zampakou

Donghi

2016

Journal of Inorganic Biochemistry

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Targeting nucleic acids with metal complexes is an exciting and widely explored field of research. Following the discovery of the anticancer drug cisplatin, a number of metal complexes have been designed, synthesised, and tested for their DNA binding properties. On the contrary, the interaction of metal complexes with RNA has been much less investigated. RNA is an essential biomolecule, involved in a variety of crucial cellular functions, which offers a much wider structural diversity than DNA. As such, RNA represents an attractive target for the design and the development of structure-selective therapeutic and diagnostic agents. A few recent publications describe the ability of various metal complexes to interact with RNA, and the binding of cisplatin and derivatives to RNA is being currently investigated. This short review offers an overview of some recent advances on both covalent and non-covalent interactions of metal complexes with RNA and addresses the potential of targeting RNA non-duplex structures.

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Salphen metal complexes as tunable G-quadruplex binders and optical probes

Cited by 79 publications

References 32 publications

New Ruthenium‐Based Probes for Selective G‐Quadruplex Targeting

New Ruthenium‐Based Probes for Selective G‐Quadruplex Targeting

Introducing Metallosalens into Biological Studies: The Renaissance of Traditional Coordination Complexes

Covalent and non-covalent binding of metal complexes to RNA

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