Salphen metal complexes as potential anticancer agents: interaction profile and selectivity studies toward the three G-quadruplex units in the KIT promoter

Abstract

DNA G-rich sequences can organize in four-stranded structures called G-quadruplexes (G4s). These motifs are enriched in significant sites within the human genomes, including telomeres and promoters of cancer related genes....

How the Metal Ion Affects the 1H NMR Chemical Shift Values of Schiff Base Metal Complexes: Rationalization by DFT Calculations

“…Solvents and reagents (reagent grade) were all commercially available and used without further purification. All the compounds are literature known and were prepared according to or slightly modifying the reported procedures …”

“…In the past few years, we have been involved in the synthesis and characterization of square planar Schiff base transition-metal complexes, also investigating their DNA-binding properties. − In this context, we have recently reported on different metal complexes of a substituted Salphen ligand, H 2 L1 in Figure . In these complexes, the metal ion is always charged 2+ and copper­(II) is also included.…”

Synthesis and biological evaluation of salophen nickel(II) and cobalt(III) complexes as potential anticancer compounds

“…The mode of action of such compounds is described as association with G‐quadruplex deoxyribonucleic acid (DNA) and inhibition of telomerase. [ 24–30 ]…”

“…The mode of action of such compounds is described as association with G-quadruplex deoxyribonucleic acid (DNA) and inhibition of telomerase. [24][25][26][27][28][29][30] The influence of substituents at the salicylidene moieties on the antitumor activity has already been studied in our group. The most promising [N,N'-bis(3-methoxysalicylidene)-1,2-phenylenediamine] nickel(II) complex showed strong inhibition of cell proliferation, high apoptosis induction, and the competence to overcome resistance against vincristine in Burkitt-like lymphoma (BJAB) and human B-cell precursor (Nalm-6) cells.…”

G-quadruplex DNA selective targeting for anticancer therapy: a computational study of a novel PtII monofunctional complex activated by adaptive binding

“…Pt II complexes can achieve a relatively high binding affinity to G-Qs that can be properly tuned by varying the ligands. [14][15][16][17][18] Nevertheless, the square-shaped coordination to the Pt II cation that provides the necessary planar geometry for good π-π stacking with G-quartets is the cause of poor selectivity over duplex DNA. 19 Recently, the synthesis and characterization of a new Pt II complex able to manifest its selective binding activity only after activation have been reported.…”