Salophen Anchored Silver Nanoparticle as Nanoprobe Designed for Selective Sensing and Antibacterial Activity
Tankadhar Behera,
Biswaprakash Sarangi,
Dhananjaya Mishra
et al.
Abstract:Indeed, considerable efforts have been made in the domain of silver nanoparticles, including the construction and wide‐ranging applications. This work involves the synthesis and characterization of salophen anchored silver nanoparticles (AgNPs), and its utilization for selective detection of Fe2+ and Cu2+ ions in DMSO. These AgNPs were synthesized by the reduction of Ag+ ions with salophen ligand, and were characterized by different techniques which include UV‐visible, fluorescence, FTIR, SEM, EDX, TEM, PXRD, … Show more
“…This alarming trend, coupled with the prolonged and costly process of developing new antibiotics, underscores the urgent need for alternative antimicrobial strategies [ 5 ]. In this context, silver nanoparticles (AgNPs) have emerged as promising candidates due to their potent bactericidal properties and broad-spectrum activity against various bacterial strains [ 6 , 7 , 8 , 9 , 10 ]. However, despite their effectiveness, concerns regarding the toxicity of AgNPs to human cells and their potential environmental impact have raised apprehensions about their widespread use [ 11 , 12 ].…”
The emergence of antibiotic-resistant bacteria necessitates the development of novel, sustainable, and biocompatible antibacterial agents. This study addresses cytotoxicity and environmental concerns associated with traditional silver nanoparticles (AgNPs) by exploring lignin, a readily available and renewable biopolymer, as a platform for AgNPs. We present a novel one-pot synthesis method for lignin-based AgNPs (AgNPs@AL) nanocomposites, achieving rapid synthesis within 5 min. This method utilizes various organic solvents, demonstrating remarkable adaptability to a wide range of lignin-dissolving systems. Characterization reveals uniform AgNP size distribution and morphology influenced by the chosen solvent. This adaptability suggests the potential for incorporating lignin-loaded antibacterial drugs alongside AgNPs, enabling combined therapy in a single nanocomposite. Antibacterial assays demonstrate exceptional efficacy against both Gram-negative and Gram-positive bacteria, with gamma-valerolactone (GVL)-assisted synthesized AgNPs exhibiting the most potent effect. Mechanistic studies suggest a combination of factors contributes to the antibacterial activity, including direct membrane damage caused by AgNPs and sustained silver ion release, ultimately leading to bacterial cell death. This work presents a straightforward, adaptable, and rapid approach for synthesizing biocompatible AgNPs@AL nanocomposites with outstanding antibacterial activity. These findings offer a promising and sustainable alternative to traditional antibiotics, contributing to the fight against antibiotic resistance while minimizing environmental impact.
“…This alarming trend, coupled with the prolonged and costly process of developing new antibiotics, underscores the urgent need for alternative antimicrobial strategies [ 5 ]. In this context, silver nanoparticles (AgNPs) have emerged as promising candidates due to their potent bactericidal properties and broad-spectrum activity against various bacterial strains [ 6 , 7 , 8 , 9 , 10 ]. However, despite their effectiveness, concerns regarding the toxicity of AgNPs to human cells and their potential environmental impact have raised apprehensions about their widespread use [ 11 , 12 ].…”
The emergence of antibiotic-resistant bacteria necessitates the development of novel, sustainable, and biocompatible antibacterial agents. This study addresses cytotoxicity and environmental concerns associated with traditional silver nanoparticles (AgNPs) by exploring lignin, a readily available and renewable biopolymer, as a platform for AgNPs. We present a novel one-pot synthesis method for lignin-based AgNPs (AgNPs@AL) nanocomposites, achieving rapid synthesis within 5 min. This method utilizes various organic solvents, demonstrating remarkable adaptability to a wide range of lignin-dissolving systems. Characterization reveals uniform AgNP size distribution and morphology influenced by the chosen solvent. This adaptability suggests the potential for incorporating lignin-loaded antibacterial drugs alongside AgNPs, enabling combined therapy in a single nanocomposite. Antibacterial assays demonstrate exceptional efficacy against both Gram-negative and Gram-positive bacteria, with gamma-valerolactone (GVL)-assisted synthesized AgNPs exhibiting the most potent effect. Mechanistic studies suggest a combination of factors contributes to the antibacterial activity, including direct membrane damage caused by AgNPs and sustained silver ion release, ultimately leading to bacterial cell death. This work presents a straightforward, adaptable, and rapid approach for synthesizing biocompatible AgNPs@AL nanocomposites with outstanding antibacterial activity. These findings offer a promising and sustainable alternative to traditional antibiotics, contributing to the fight against antibiotic resistance while minimizing environmental impact.
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