Salmonella typhi and Gallbladder Cancer

Ferreccio, Catterina

doi:10.1007/978-94-007-2585-0_5

Cited by 10 publications

(16 citation statements)

References 63 publications

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“…Similarly, another study showed that intratumoral injection of an attenuated strain of C. novyi reduced tumor volume in several preclinical animal models as well as in one phase I study on a human with metastatic disease (27). Salmonella has also been used as a vector in this case for cytosine deaminase and nitroreductase which exhibited anti-cancer effects in vivo (28).…”

Section: Microbiology and Cancermentioning

confidence: 98%

“…Spores of anaerobic bacteria can reach and germinate only in oxygen-poor tumor regions and become activated. Many anaerobic bacterial species such as Bifidobacteria, pathogenic Clostridia, and Lactobacilli have thus been tested for their anti-tumor effects (28). Deletion experiments on Salmonella typhimurium identified two genes (msbB and purl) involved in anti-cancer effects, including effects at secondary sites (28).…”

Section: Microbiology and Cancermentioning

confidence: 99%

“…Many anaerobic bacterial species such as Bifidobacteria, pathogenic Clostridia, and Lactobacilli have thus been tested for their anti-tumor effects (28). Deletion experiments on Salmonella typhimurium identified two genes (msbB and purl) involved in anti-cancer effects, including effects at secondary sites (28). Several other strains of bacteria such as Listeria monocytogenes, Escherichia coli, Vibrio cholera, and S. cholerasuis have also been examined as possible anticancer agents (26,28).…”

Section: Microbiology and Cancermentioning

confidence: 99%

“…Bacterial toxins have been tested as possible anti-cancer agents in many models and found to kill cancer cells or alter their activities related to apoptosis, proliferation and differentiation (18,28). Cytolethal distending toxins (CDTs) and cycle inhibiting factor (CIF) inhibit mitosis, whereas bacterial "cyclomodulins" disrupt host cell metabolism (34).…”

Section: Microbiology and Cancermentioning

confidence: 99%

“…The symbiotic relationship between the microbiome and the human host has significant implications on various mechanisms ranging from immune regulation to metabolism. In particular, distinct imbalances in oral and gut microbiota have been implicated in various cancers including oral squamous cell carcinoma, esophageal cancer, pancreatic cancer, gall bladder cancer, and colorectal cancer (28,36). It is important to emphasize, therefore, that a healthy lifestyle that helps maintain well-balanced microbiota can also be a crucial factor in preventing cancer.…”

Section: Microbiology and Cancermentioning

confidence: 99%

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Cancer in North Cyprus: 2. Biomedical Research Activities

Djamgoz¹,

Akün²,

Arslan³

et al. 2017

Cyprus J Med Sci

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This is the second part of a two-part review on the cancer status of North Cyprus. Here, we give an overview of the various areas of research on cancer. There are four main areas of ongoing biomedical investigation. First, monitoring of possible carcinogenic chemical factors in the environment (soil and water) is focused on arsenic. Arsenic has been found to exist broadly over the island at levels above the minimum level advised by the Environmental Protection Agency. At present, the source(s) of environmental arsenic is unclear. Second, pathophysiological mechanisms of breast and prostate cancer are being investigated with a focus on ion channels (particularly, the voltage-gated sodium channel) driving the metastatic process. In particular, the triangular relationship involving the channel, its persistent current component, and tumor hypoxia is being elucidated. Third, a further emerging theme is the association of microbiota with cancer. The possible roles of bacterial infections or microbiota in preventing, treating, or causing several types of cancers are among these projects. Fourth, a range of developments in nanotechnology is being considered. It is concluded that the island offers significant opportunities for internationally competitive, multi-faceted research on cancer.

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Section: Microbiology and Cancermentioning

confidence: 98%

Section: Microbiology and Cancermentioning

confidence: 99%

Section: Microbiology and Cancermentioning

confidence: 99%

Section: Microbiology and Cancermentioning

confidence: 99%

Section: Microbiology and Cancermentioning

confidence: 99%

See 3 more Smart Citations

Cancer in North Cyprus: 2. Biomedical Research Activities

Djamgoz¹,

Akün²,

Arslan³

et al. 2017

Cyprus J Med Sci

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Salmonella entericaserovar Typhi and gallbladder cancer: a case–control study and meta‐analysis

et al. 2016

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In Chile, where gallbladder cancer (GBC) rates are high and typhoid fever was endemic until the 1990s, we evaluated the association between Salmonella enterica serovar Typhi (S. Typhi) antibodies and GBC. We tested 39 GBC cases, 40 gallstone controls, and 39 population‐based controls for S. Typhi Vi antibodies and performed culture and quantitative polymerase chain reaction for the subset with bile, gallstone, tissue, and stool samples available. We calculated gender and education‐adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association with GBC. We also conducted a meta‐analysis of >1000 GBC cases by combining our results with previous studies. GBC cases were more likely to have high Vi antibody titer levels than combined controls (OR: 4.0, 95% CI: 0.9–18.3), although S. Typhi was not recovered from bile, gallstone, tissue, or stool samples. In our meta‐analysis, the summary relative risk was 4.6 (95% CI: 3.1–6.8, P heterogeneity=0.6) for anti‐Vi and 5.0 (95% CI: 2.7–9.3, P heterogeneity = 0.2) for bile or stool culture. Our results are consistent with the meta‐analysis. Despite differences in study methods (e.g., S. Typhi detection assay), most studies found a positive association between S. Typhi and GBC. However, the mechanism underlying this association requires further investigation

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