Salmonella-Escherichia coli/Mammalian-Microsome Reverse Mutation Assay with a Confirmatory Assay with Dimethylamino ethylazide (DMAZ)

Abstract

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Glucosamine effects in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy

“…Results from this assay indicate that under the conditions of this study, glucosamine HCl did not cause a positive increase in the mean number of revertants per plate with any of the tester strains. These test results indicate that glucosamine is not mutagenic (Mecchi, 2003).…”

“…In unpublished studies performed by Cargill, the mutagenic activity of glucosamine HCl (REGENA-SURE TM serif) was evaluated in the Salmonella-Eschericia coli/Mammalian-Microsome Reverse Mutation Assay (Mecchi, 2003). Tester strains used in the mutagenicity assay were Salmonella typhimurium tester strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2uvrA.…”

Review of genotoxicity studies of glyphosate and glyphosate-based formulations

“…Only one of the studies exhibited revertants/plate for some strains exceeding up to three-fold of the control value (Mecchi et al, 2003a). However, these increases were not reproducible between experiments and did not exhibit a dose-response pattern.…”

Opinion of the safety of glucosamine hydrochloride from Aspergillus niger as food ingredient

“…The applicant has evaluated the mutagenic activity of the RGHAN glucosamine hydrochloride in the Salmonella-Escherichia coli reverse mutation assay (Mecchi, 2003). The tester strains used were Salmonella enterica var.…”