2007
DOI: 10.1371/journal.pbio.0050244
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Salmonella enterica Serovar Typhimurium Exploits Inflammation to Compete with the Intestinal Microbiota

Abstract: Most mucosal surfaces of the mammalian body are colonized by microbial communities (“microbiota”). A high density of commensal microbiota inhabits the intestine and shields from infection (“colonization resistance”). The virulence strategies allowing enteropathogenic bacteria to successfully compete with the microbiota and overcome colonization resistance are poorly understood. Here, we investigated manipulation of the intestinal microbiota by the enteropathogenic bacterium Salmonella enterica subspecies 1 ser… Show more

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Cited by 930 publications
(1,020 citation statements)
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References 62 publications
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“…Twelve-week-old FVB/N CEABAC10 transgenic male mice (body weight, 26 to 28 g) that expressed human CEACAM6 were first pretreated orally with the broad-spectrum antibiotic streptomycin (5 mg per mouse administered intragastrically) to disrupt the normal resident bacterial flora in the intestinal tract (34) and then orally challenged with 10 9 bacteria 24 h later. The animals received an extremely low dose of 0.25% (wt/vol) dextran sulfate sodium (DSS; molecular mass, 36,000 to 50,000 Da; MP Biomedicals) in their drinking water starting 3 days before infection to increase the bacteria's accessibility to the surface of the epithelial layer.…”
Section: Methodsmentioning
confidence: 99%
“…Twelve-week-old FVB/N CEABAC10 transgenic male mice (body weight, 26 to 28 g) that expressed human CEACAM6 were first pretreated orally with the broad-spectrum antibiotic streptomycin (5 mg per mouse administered intragastrically) to disrupt the normal resident bacterial flora in the intestinal tract (34) and then orally challenged with 10 9 bacteria 24 h later. The animals received an extremely low dose of 0.25% (wt/vol) dextran sulfate sodium (DSS; molecular mass, 36,000 to 50,000 Da; MP Biomedicals) in their drinking water starting 3 days before infection to increase the bacteria's accessibility to the surface of the epithelial layer.…”
Section: Methodsmentioning
confidence: 99%
“…These data are in agreement with previous work showing signs of recovery (reappearance of the intestinal epithelium and goblet cells) at day 20 post infection in 129Sv/Ev mice infected with Salmonella Typhimurium. 18 Overall, the pathologic scores observed on the mixed background of ITY9 mice were higher than those observed in pure 129S6 or C57BL/6J background demonstrating the impact of the background on the expression of the phenotype.…”
Section: Discussionmentioning
confidence: 82%
“…8 Other groups have compared the impact of the genetic background on disease manifestation and found no difference between the C57BL/6J and 129Sv/Ev background early after infection. 18 These discrepancies could be explained by the fact that the different studies used different 129 substrains; although closely related, different 129 substrains still present an important genetic diversity. As an example, we have identified 19 545 single-nucleotide polymorphisms between 129S1 and 129X1 using the Diversity Mouse Genotyping Array (unpublished data).…”
Section: Discussionmentioning
confidence: 99%
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“…Elimination of gut normal microflora with antibiotics contributes to high susceptibility of mice to experimental colitis induction with dextran sodium sulfate (DSS) [43]. An entropathogenic bacterium Salmonella enterica inhibits the growth of microbiota in the gut and subsequently predisposes mice to colitis development [44]. Alteration of the gut microbiome by antibiotics in humnas can lead to the development of pathogenic Clostridium difficile infection [45].…”
Section: Intestinal Homeostasis and Immune Responsesmentioning
confidence: 99%