“…Various animal and tissue models have been established in swine for investigation of mucosal immune mechanisms and induction of protective memory. They include respiratory models of bacterial and viral infection (Baarsch et al, 2000; Baarsch et al, 1995; Saif, 1996; Saif et al, 1994; VanCott et al, 1994), enteric viral infection and defined antigen models (Brim et al, 1995; Foss and Murtaugh, 1999a, 2000; Hyland et al, 2004; Hyland et al, 2006b; Lanza et al, 1995; Saif, 1999; VanCott et al, 1993), ex vivo secretory tissue preparations in Ussing chambers, and epithelial transwell cell culture systems (Gookin et al, 2004; Hyland et al, 2006a; Schmidt et al, 2007). …”