Salmonella enterica serovar Abortusequi as an emergent pathogen causing equine abortion in Argentine

Bustos, C.P.; Retamar, G.; Lanza, Natalia; Falzoni, E.; Caffer, María Inés; Picos, Jorge; Muñoz, A.J.; Perez, Ana V.; Moras, E.V.; Mesplet, María; Guida, Nora

doi:10.1016/j.jevs.2016.02.127

Cited by 12 publications

(19 citation statements)

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“…For example, the organism has been more frequently reported in Japan and has re−emerged in Argentina . Though common in horses , there has been no report about abortion in donkeys caused by S. abortus equi . The purpose of the current report is to describe abortions in donkeys caused by S. abortus equi in China and to document the existence of antigen variation in isolated strains in attempt to provide information to veterinarians.…”

Section: Introductionmentioning

confidence: 99%

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Abortion in donkeys associated with Salmonella abortus equi infection

Wang¹,

Liu²,

Sun³

et al. 2019

Equine Veterinary Journal

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Summary Background Salmonella enterica subspecies enterica serovar abortus equi (S. abortus equi) is well known as the aetiological agent of equine abortion. However, abortion caused by S. abortus equi has not been previously described in donkeys. Objectives To investigate whether S. abortus equi was correlated with an abortion outbreak consisting of 61 abortions. Study design Investigation of the clinical cases using pathoanatomical, bacteriological, serological and molecular approaches. Methods Autopsies on nine aborted foetuses were performed. Tissue specimens from seven aborted foetuses and two mares were cultured and subjected to detection of equine herpesvirus 1 (EHV‐1), equine herpesvirus 4 (EHV‐4) and equine arteritis virus (EAV) by polymerase chain reaction. The isolates were serotyped according to the Kaufmann−White scheme and analysed by multi‐locus sequence typing (MLST). Detection of EHV and EAV antibodies was performed in all pregnant mares. Results No obvious gross lesions were observed in the foetuses. Nine Gram‐negative isolates were obtained from all nine tissue samples and were identified as Salmonella spp. All of the isolates belonged to the B group, the O antigen epitope was 4, 12 and H antigen was not obtained. The isolates of Salmonella were characterised as sequence type (ST) 251. Detection of EHV‐1, EHV‐4 and EAV was negative. Main limitations The mechanism that causes abortion in donkeys needs further study and the lack of histological examination. Conclusion Salmonella abortus equi was isolated as the single agent and was responsible for the abortions. Equine practitioners should be aware of S. abortus equi infection as a cause of abortion in donkeys.

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Section: Introductionmentioning

confidence: 99%

“…For example, the organism has been more frequently reported in Japan and has reÀemerged in Argentina [5,7]. Though common in horses [2,8,9], there has been no report about abortion in donkeys caused by S. abortus equi.…”

Section: Introductionmentioning

confidence: 99%

Abortion in donkeys associated with Salmonella abortus equi infection

Wang¹,

Liu²,

Sun³

et al. 2019

Equine Veterinary Journal

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“…Between the 1950s and 1970s, mares with reproductive pathologies caused by S. Abortusequi were described in Argentina, the United States and several countries from Europe (Albania, Italy and Croatia), Asia (India and Japan) and Africa (Cameroon) [1][2][3][4][5]. The disease has been involved in abortion storms causing large economical loses in Argentina and Japan [3,[6][7][8]. Since 2011, equine paratyphoid abortion has been affecting Argentine equine industry as a re-emerging disease causing abortion storms involving large numbers of infected mares in short periods of time [6][7][8] and many foals were born infected and manifesting septic arthritis (Ivanissevich, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…The disease has been involved in abortion storms causing large economical loses in Argentina and Japan . Since 2011, equine paratyphoid abortion has been affecting Argentine equine industry as a re‐emerging disease causing abortion storms involving large numbers of infected mares in short periods of time and many foals were born infected and manifesting septic arthritis (Ivanissevich, 2016). While the microorganism is considered as an eradicated pathogen in the United States, its isolation in Europe seems to be sporadic.…”

Section: Introductionmentioning

confidence: 99%

Genotypic diversity of Salmonella ser. Abortusequi isolates from Argentina

Bustos

Moroni²,

Caffer³

et al. 2019

Equine Veterinary Journal

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Summary Background Salmonella enterica subsp. enterica serovar Abortusequi (S. Abortusequi) is a serotype restricted to equines, which produces abortion outbreaks. Nowadays the disease is being reported in different countries including Argentina thus generating an important impact in the equine industry. Molecular characterization of the 95 kb virulence plasmid and the spvC gene of S. Abortusequi demonstrated their importance in the pathogenicity of the serotype. In the last decades, high clonality of S. Abortusequi was identified in Japan, Mongolia and Croatia. Objectives The aim of this work was to characterize S. Abortusequi isolates obtained in Argentina between 2011 and 2016 by virulence‐gene profiling and pulsed‐field gel electrophoresis. Study design Case report. Methods S. Abortusequi isolates were studied by virulence‐gene profiling and pulsed‐field gel electrophoresis. Results Four virulence profiles and nine pulsed‐field gel electrophoresis pulsotypes were identified among the 27 isolates included in the study. Different strains were found in the same outbreak and/or farm suggesting the presence of different sources of infection or mutation of isolates. Main limitations The number of related and nonrelated strains. More isolates may be necessary for a more intensive study. Conclusions Most strains presented the same virulence profile, being positive for all the studied genes except gipA and sopE1, which are involved in intestinal virulence. Only few isolates showed different results in the same outbreak or farm. Unlike other studies, our results demonstrate a considerable diversity of S. Abortusequi pulsed‐field gel electrophoresis pulsotypes, which suggests that different sources of infection may be involved within the same outbreak.

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“…18,19 Although reported commonly from Asian and African countries, S. Abortusequi is only isolated sporadically in Europe, the United States, and Argentina. 3,9,12-14,16…”

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High mortality in foals associated with Salmonella enterica subsp. enterica Abortusequi infection in Italy

et al. 2018

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Salmonella enterica subsp. enterica serovar Abortusequi is frequently reported as a cause of abortion in mares and neonatal septicemia and polyarthritis in Asian and African countries, but only sporadically in Europe and the United States. We report an outbreak of S. Abortusequi in foals in Italy, characterized by high mortality. In a herd of Murgese horses, 10 of 34 newborns died at birth and a further 7 died, after developing severe clinical signs, during the first 10 d of life. Tissue specimens from different organs of 2 dead foals, synovial fluids from 4 sick foals, and vaginal and rectal swabs from their dams were cultured. A total of 16 isolates, all as pure cultures, were obtained and identified as Salmonella. The isolates exhibited the same antimicrobial resistance pattern and the same sequence type, ST251, a type that has been associated with S. Abortusequi. Six of 16 isolates were serotyped and found to be S. Abortusequi 4,12:-:e,n,x. Equine practitioners should be aware of S. Abortusequi infection as a cause of neonatal mortality in foals.

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Salmonella enterica serovar Abortusequi as an emergent pathogen causing equine abortion in Argentine

Cited by 12 publications

References 0 publications

Abortion in donkeys associated with Salmonella abortus equi infection

Abortion in donkeys associated with Salmonella abortus equi infection

Genotypic diversity of Salmonella ser. Abortusequi isolates from Argentina

High mortality in foals associated with Salmonella enterica subsp. enterica Abortusequi infection in Italy

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