Salmonella enterica Arthritis in a Patient with Rheumatoid Arthritis Receiving Anti-tumour Necrosis Factor Therapy

Abstract

Anti-tumour necrosis factor (TNF) monoclonal antibodies have become an invaluable treatment against chronic inflammatory diseases such as rheumatoid arthritis (RA). However, due to increased risk of opportunistic infections, patients receiving anti-TNF therapy should be closely monitored for serious infections. Here, we describe a case of acute Salmonella enteritidis infection of a joint arthroplasty that previously was functioning well, in a patient receiving infliximab treatment for RA. After prolonged antimicrobial chemotherapy and interrupted infliximab treatment, reimplantation of a new prosthesis was successfully performed two years after Salmonella septic arthritis. Therefore, because of the possibility of extraintestinal salmonellosis, screening for fecal colonization could be advisable in patients undergoing anti-TNF treatment. Moreover, we emphasize the importance of appropriate counselling of these patients concerning food hygiene.

Human gingival tissue-derived MSC suppress osteoclastogenesis and bone erosion via CD39-adenosine signal pathway in autoimmune arthritis

“…Clinical drug development for rheumatologists has progressed slowly. RA patients are normally treated with disease-modifying anti-rheumatic drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs) [1,3], TNF inhibitors [4,5], IL-1 antagonists [6], and/or IL-6 receptor antibody [7,8]. Cumulatively, among the therapeutic approaches, none is curative for RA patients, leading investigators to search novel approaches for this common autoimmune disorder [9].…”

Adipose‐derived mesenchymal stromal cells suppress osteoclastogenesis and bone erosion in collagen‐induced arthritis

“…Clinical drug development for the treatment of RA has progressed slowly. Usually, non‐steroidal anti‐inflammatory drugs (NSAIDs) 3,4 and other cytokine inhibitors such as TNF inhibitors, 5,6 IL‐1 antagonists 7 and IL‐6 receptor antibody 8,9 were used to treat RA. However, none are curative for RA.…”