Salix eleagnos Scop. – a novel source of antioxidant and anti-inflammatory compounds: Biochemical screening and in silico approaches

Gligorić, Emilia; Igić, Ružica; Suvajdžić, Ljiljana; Teofilović, Branislava; Grujić-Letić, Nevena

doi:10.1016/j.sajb.2019.11.018

Cited by 12 publications

(15 citation statements)

References 36 publications

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“…The results showed a higher selectivity of the ME towards inhibition of COX-2 than COX-1 (SI = 2.06). It has previously been demonstrated that the flavonoids quercetin and naringenin, as well as the phenolic acids rosmarinic and chlorogenic acids, have high binding affinity and good hydrogen bond interactions with the active site residues of both COX-1 and COX-2 [ 29 ]. In silico experiments also revealed the possible inhibition of COX-1 and COX-2 by quercetin and quercetin derivatives [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

Ferocactus herrerae Fruits: Nutritional Significance, Phytochemical Profiling, and Biological Potentials

Abdel-Baki

Ibrahim

Mahdy

2022

Plant Foods Hum Nutr

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The current study reports for the first time the nutritional, fruit volatiles, phytochemical, and biological characteristics of Ferocactus herrerae J. G. Ortega fruits. The nutritional analysis revealed that carbohydrate (20.6%) was the most abundant nutrient followed by dietary fibers (11.8%), lipids (0.9%), and proteins (0.8%). It was rich in vitamins, minerals, essential, and non-essential amino acids. Gas chromatography-mass spectrometry (GC-MS) analysis of the headspace-extracted volatiles showed that 3-methyl octadecane (35.72 ± 2.38%) was the major constituent detected. Spectrophotometric determination of total phenolic and flavonoid contents of the fruit methanolic extract (ME) showed high total phenolic [9.17 ± 0.87 mg/g gallic acid equivalent (GAE)] and flavonoid [4.99 ± 0.23 mg/g quercetin equivalent (QE)] contents. The ME was analyzed using high-performance liquid chromatography with ultraviolet (HPLC-UV), which allowed for both qualitative and quantitative estimation of 16 phenolic compounds. Caffeic acid was the major phenolic acid identified [45.03 ± 0.45 mg/100 g dried powdered fruits (DW)] while quercitrin (52.65 ± 0.31 mg/100 g DW), was the major flavonoid detected. In-vitro assessment of the antioxidant capacities of the ME revealed pronounced activity using three comparative methods; 2, 2-diphenyl-1-picrylhydrazyl (DPPH) (132.06 ± 2.1 μM Trolox equivalent (TE) /g), 2,2′-azino-di(3-ethylbenzthiazoline-6-sulfonic acid (ABTS), (241.1 ± 5.03 uM TE/g), and ferric reducing antioxidant power (FRAP) (258.9 ± 1.75 uM TE/g). Besides, remarkable anti-inflammatory [COX-1 (IC50 = 20.2 ± 1.1 μg/mL) and COX-2 (IC50 = 9.8 ± 0.64 μg/mL)] and acetylcholinesterase inhibitory (IC50 = 1.01 ± 0.39 mg/mL) activities were observed. Finally, our results revealed that these fruits could be used effectively as functional foods and nutraceuticals suggesting an increase in their propagation.

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Section: Resultsmentioning

confidence: 99%

Ferocactus herrerae Fruits: Nutritional Significance, Phytochemical Profiling, and Biological Potentials

Abdel-Baki

Ibrahim

Mahdy

2022

Plant Foods Hum Nutr

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“…The bark of the willow tree (genus: Salix ) is a sumptuous natural source of invaluable bioactive compounds like phenolic glycosides, flavonoids and polyphenols (Mahdi, 2010). Salicylic acid (derived from salicin), one of the oldest medicinal compounds was discovered from this tree, which went on to become one of the major classes of anti‐inflammatory, anti‐rheumatic, antipyretic and analgesic drugs (Gligorić et al, 2020). Apart from that they also possess glycemia and prothrombin‐modulating aspects (Shara & Stohs, 2015).…”

Section: Herbal Interventions With Potential Anti‐rheumatic Activitymentioning

confidence: 99%

Comprehensive insights into rheumatoid arthritis: Pathophysiology, current therapies and herbal alternatives for effective disease management

Chatterjee,

Jayaprakasan,

Chakrabarty

et al. 2024

Phytotherapy Research

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Rheumatoid arthritis is a chronic autoimmune inflammatory disease characterized by immune response overexpression, causing pain and swelling in the synovial joints. This condition is caused by auto‐reactive antibodies that attack self‐antigens due to their incapacity to distinguish between self and foreign molecules. Dysregulated activity within numerous signalling and immunological pathways supports the disease's development and progression, elevating its complexity. While current treatments provide some alleviation, their effectiveness is accompanied by a variety of adverse effects that are inherent in conventional medications. As a result, there is a deep‐rooted necessity to investigate alternate therapeutic strategies capable of neutralizing these disadvantages. Medicinal herbs display a variety of potent bioactive phytochemicals that are effective in the complementary management of disease, thus generating an enormous potency for the researchers to delve deep into the development of novel phytomedicine against autoimmune diseases, although additional evidence and understanding are required in terms of their efficacy and pharmacodynamic mechanisms. This literature‐based review highlights the dysregulation of immune tolerance in rheumatoid arthritis, analyses the pathophysiology, elucidates relevant signalling pathways involved, evaluates present and future therapy options and underscores the therapeutic attributes of a diverse array of medicinal herbs in addressing this severe disease.

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“…In medicine, squalene is added as a component of agents for the external therapy of inflammatory skin diseases. In this case, the property of squalene to deeply penetrate the skin, being able to carry elements of other compounds, is used; as a result, potent medicines can be applied on the skin pointwise, not being troubled of their adverse effects [31].…”

Section: Content Of Volatile Compoundsmentioning

confidence: 99%

Phytochemical Research and Antimicrobial Properties of Lipophylic Extracts of Some Species of Salix L. Genus from Ukraine

Borodina¹,

Raal²,

Kovalyov³

et al. 2020

TOASJ

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Background: Willows are indispensable for the creation of anti-erosion plantations, preliminary soil-improving crops in the reclamation of disturbed lands, as well as for energy plantations designed to produce the biomass suitable for biofuels. In the process of care and thinning of these plantations, there are a huge amount of waste remains - young willow branches and leaves, which would be advisable to use in medical and pharmaceutical practice to create new supplements and medicines. They are known to possess antimicrobial, antifungal, and antiviral properties. Objective: The aim of the current paper is to determine the chemical composition of lipophylic extracts of some species of Salix L. genus and to study their antimicrobial properties. Methods: The lipophylic extracts from Salix cinerea L., S. incana Schrank, S. cаprea L., S. sachalinensis F. Schmidt, S. acutifolia L., S. fragilis L., S. caspica Pall., S. rosmarinifolia L. and S. myrsinifolia Salisb. fresh shoots were obtained using chloroform in the Soxhlet apparatus. The composition of volatile components and carboxylic acids was determined using quantitative content of chlorophylls and carotenoids was measured spectrophotometrically. The antibacterial activity was studied by the agar diffusion method. Results: The methods used allowed identifying 46 volatile compounds in the lipophylic extracts from the shoots of the plants of Salix L. genus, where eugenol and squalene dominated; as well as 42 organic acids, among which benzoic, methoxybenzoic, salicylic acids prevailed, and palmitic, linoleic and linolenic acids were found to prevail among fatty acids. All lipophylic extracts studied showed antimicrobial activity against Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Bacillus subtilis and Candida albicans. Conclusion: The results obtained indicate the possibility of the creation of a novel antimicrobial agent using the lipophylic extracts from the shoots of Salix L. genus rich in different biologically active substances.

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Salix eleagnos Scop. – a novel source of antioxidant and anti-inflammatory compounds: Biochemical screening and in silico approaches

Cited by 12 publications

References 36 publications

Ferocactus herrerae Fruits: Nutritional Significance, Phytochemical Profiling, and Biological Potentials

Ferocactus herrerae Fruits: Nutritional Significance, Phytochemical Profiling, and Biological Potentials

Comprehensive insights into rheumatoid arthritis: Pathophysiology, current therapies and herbal alternatives for effective disease management

Phytochemical Research and Antimicrobial Properties of Lipophylic Extracts of Some Species of Salix L. Genus from Ukraine

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