Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis

Corvo, M.; Eckley, Claudia Alessandra; Rizzo, Luis V.; Sardinha, Luiz Roberto; Navarro–Rodriguez, Tomás; Filho, Ivo Bussoloti

doi:10.1016/j.bjorl.2014.08.006

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…Regarding the development of roughness, some studies proposed that the most possible negative factors altering the periodicity of the vibration cycle and glottic closure would be slight edema of the vibratory margin of the vocal cords, which is caused by potentially noxious materials including gastric acid, pepsin and pancreatic enzyme irritation [13]. Other authors proposed that dryness (sticky laryngeal mucus), keratosis of the vibratory margin of the vocal folds, thickening of the epithelium, ulcerative lesions, granulomas and modifications of the Reinke space would form the basis of the alteration of the vibratory function of the vocal folds, especially in mild or moderate LPR patients [46]. Many of these conditions altering the mechanical and vibration characteristics of the vocal folds are not described in RFS and may lead to the development of roughness.…”

Section: Discussionmentioning

confidence: 99%

Impact of laryngopharyngeal reflux on subjective and objective voice assessments: a prospective study

Lechien

Huet

Khalifé

et al. 2016

J of Otolaryngol - Head & Neck Surg

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BackgroundLaryngopharyngeal reflux is a prevalent, not well-understood disease affecting a high proportion of patients who seek laryngology consultation. The objective of this prospective case series is to explore the subjective and objective voice modifications in Laryngopharyngeal reflux (LPR), especially the usefulness of acoustic parameters as treatment outcomes, and to better understand the pathophysiological mechanisms underlying the development of voice disorder.MethodsForty-one patients with a reflux finding score (RFS) > 7 and a reflux symptom index (RSI) > 13 were enrolled and treated with pantoprazole 20 mg twice daily for three months. RSI, RFS, Voice Handicap Index (VHI), and Grade, Roughness, Breathiness, Asthenia, Strain and Instability (GRBASI) were assessed at baseline and after three months post-therapy. Acoustic parameters were measured by selecting the most stable interval of the vowel /a/. A study of correlations between acoustic measurements and laryngoscopic signs was conducted in patients with roughness. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS).ResultsSignificant improvement in RSI, RFS, VHI, jitter, percent jitter, relative average perturbation (RAP), shimmer, percent shimmer, and amplitude perturbation quotient (APQ) was found at 3 months of treatment (p < .05). A correlation analysis revealed significant correlations between the grade of dysphonia, breathiness, asthenia, instability and jitter, percent jitter, RAP, shimmer, percent shimmer and APQ. In dividing our cohort into two groups of patients according to the presence of roughness, shimmer, percent shimmer and APQ significantly improved in patients with roughness, but no positive correlation was found between acoustic parameters and laryngoscopic signs.ConclusionAcoustic parameters can help to better understand voice disorders in LPR and can be used as treatment outcomes in patients with roughness.

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Section: Discussionmentioning

confidence: 99%

Impact of laryngopharyngeal reflux on subjective and objective voice assessments: a prospective study

Lechien

Huet

Khalifé

et al. 2016

J of Otolaryngol - Head & Neck Surg

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Técnica de recolección del flujo salival no estimulado en el diagnóstico de pacientes con síndrome de Sjögren: unificando conceptos. Una revisión sistemática de la literatura

Martínez-Ceballos

Aguilera

Cajamarca

et al. 2020

Revista Colombiana de Reumatología

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Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis

Abstract: Salivary transforming growth factor alpha level was significantly higher in patients with Sjögren's syndrome and laryngopharyngeal reflux when compared to the control group.

Cited by 2 publications

References 45 publications

Impact of laryngopharyngeal reflux on subjective and objective voice assessments: a prospective study

Impact of laryngopharyngeal reflux on subjective and objective voice assessments: a prospective study

Técnica de recolección del flujo salival no estimulado en el diagnóstico de pacientes con síndrome de Sjögren: unificando conceptos. Una revisión sistemática de la literatura

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